Estrogen-related receptor gamma (ERRγ) is involved in energy metabolism, mitochondrial functions, biogenesis and tissue repair. Disorders of ERRγ are observed at type 2 diabetes, hypoxia, metabolic syndrome and cancer. Therefore, small molecule compounds modulating ERRγ activity may have significant therapeutic potential.
OTAVAchemicals offers an Estrogen Related Receptor Gamma (ERRγ) Targeted Library (878 compounds in total). This special set of compounds https://bit.ly/3NqZxVt has been carefully designed with combined approach that includes application of pharmacophore screening and molecular docking.
Pharmacophore screening was performed against pharmacophore model that was built on the basis of superposition of four crystals structure (complexes of ERRγ with antagonists and inverse agonists, PDB ID: 2E2R, 2EWP, 2GPU, 2ZAS). This model was optimized and validated using compounds with known modulating ERRγ activity taken from ChEMBL database. Top-scored compounds resulted from pharmacophore screening were compared with top-scored compounds from docking in crystal structure of ERRγ (PDB ID: 2GPU). Final selection from overlaped compounds was performed with inspection of intermolecular hydrophobic contacts and hydrogen bonds with key amino acid residues.
For ordering and additional information, please email us to info@otavachemicals.com.
Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.
Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.
We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.
Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.
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