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 | Seeking Biomanufacturing of Transformational Ingredients in Consumer-Packaged Goods |
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We are looking for approaches to engineer and optimize organisms (microbial and plant) for production and/or purification of relevant biomolecules in a non-trial-and-error format. It is believed that starting from a waste stream will be a more cost-effective solution. We are also interested in plant- or algae-based solutions that are scalable and cost effective. What We Are Looking For: • Strain engineering approaches that achieve target molecule production targets across multiple molecule classes in significantly less time versus the industry average • Host engineering capabilities in non-model systems • Scale up platforms/methods that are amenable to commodity scale ingredients • Downstream processing methods/technologies that facilitate continuous extraction and/or re-use of extractive reagents • Approaches that leverage feedstocks separate from the food chain |
| | Seeking Solutions for Repair and Protection of Enamel and Dentin |
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A product that delivers significant and long lasting repair to damaged tooth enamel and dentin |
 | Seeking a next generation material for safe Microwave, Oven and Air Fryer cooking from frozen |
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As a global market leader in the frozen food sector, Nomad Foods is seeking advanced material solutions capable of maintaining structural and chemical integrity across an extreme thermal lifecycle: from deep-freeze storage at -18°C to active cooking in microwaves, air fryers, and conventional ovens (up to 220°C). The material must not adversely affect the product in any way: Proposals must demonstrate that the material has zero organoleptic impact, ensuring no migration of taste, odor, or aroma to the food product throughout its lifecycle. To ensure the long-term sustainability of our packaging portfolio, the material must achieve a RecyClass Recyclability Assessment Method (RAM) rating of Grade A or B. This may be accomplished through the use of an appropriate barrier coating or by utilising an existing recyclable substrate. The packaging format remains open, though our preference is to identify solutions that could replace our current flexible plastic cook‑in pouches or trays. The technology we are seeking should be at the functional prototype stage. The proposed packaging format must enable a high-performance "cook-in-pack" solution for our consumers. This technology will facilitate steam-cooking directly within the bag, pouch, or enclosed material, preserving the nutritional integrity of the food. The material must offer high transparency, allowing consumers to see the product, allowing us to showcase our vibrant, high-quality ingredients, emphasizing the premium nature and freshness of the Nomad Foods portfolio. |
 | Cadherin-11 Inhibitor Formulation for Immunotherapy |
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This invention provides a novel formulation of cadherin-11 (CDH11) inhibitors for use in combination with chemotherapy and/or immunotherapy. The composition targets activated fibroblasts to treat or prevent cancer, fibrosis, and autoimmune diseases. It comprises a specific CDH11 inhibitor compound formulated with an organic solvent and polyethylene glycol, designed to enhance therapeutic efficacy when combined with other cancer treatments. |
| | Text-to-Speech (TTS): System, Apparatus, Means & Method |
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- High-quality speech synthesis across multiple languages and accents with a single voice model - Personalized speech synthesis capabilities, which enable users to utilize their own voices - Requires less training data and allows for voice transformation |
| | Engineering Stem Cell-like Memory CD4+ T Cells for Enhanced Immunotherapy |
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This invention introduces a novel method to generate stem cell-like memory T (TSCM) cells from CD4+ T cells using MEK1/2 inhibitors. These engineered TSCM cells exhibit enhanced properties including self-renewal, robust antigen-specific responses, and the ability to differentiate into various CD4+ subpopulations. This approach addresses the limitations of current T cell therapies by producing more durable and effective therapeutic cells for treating cancer, infections, and autoimmune disorders.BACKGROUND T cell therapy is a promising area in immunotherapy, but current methods face challenges such as T cell exhaustion and limited efficacy. This invention provides a solution by re-engineering CD4+ T cells into TSCM cells, offering a more robust and versatile approach to cellular immunotherapy. The technology has potential applications in various diseases, addressing the need for more effective and personalized treatments. |
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