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 | Seeking Digestive Wellness Solutions |
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We are interested in products, technologies and packaging that will improve the benefit areas of: Managing and/or enhancing Digestive Wellness; Improving the consumer usage experience and delighting our consumers; and/or Complimenting our portfolio (Metamucil, Pepto Bismol, Align). |
| | Seeking Oral Care Solutions with Novel Cleaning Agents |
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Breakthrough cleaning benefits with daily use safety profile; Exploration of alternatives to flossing. Safe and effective removal of food and debris between teeth via chemical approach that would increase compliance and enhance the oral health benefits of driven by the flossing action, without having to floss. |
| | Seeking Oral Care Solutions for Non-Bleach Whiteners |
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Breakthrough whitening benefits with daily use safety profile |
 | A Software Suit for Microbubble Enhanced HIFU for Noninvasive Ablations of Deep-seated Tumor |
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Our innovative software leads to a revolutionary breakthrough of non-invasive tumor ablations by enabling customized microbubble targeting ultrasonic therapies for deep-seated tumors in clinical setting, which works as a Virtual Lab for biomedical researchers, tumor Treatment Planning Software for therapist, and a design tool for HIFU manufactures to improve efficacy and safety of HIFU devices. |
 | NanoMEDIC gene editing delivery system |
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Background Gene therapy holds great potential for the treatment of genetic diseases. However, delivery to specific tissues is still a major bottleneck. Although AAV-delivered CRISPR-Cas9 editing is being developed for multiple diseases, its therapeutic translation is hindered by the limited packaging capacity of viral particles and possible immune response to them. Moreover, AAV transgenes tend to be expressed for an extended period of time, which increases off-target mutagenesis risk. Extracellular vesicles (EV) is another option and, when combined with ribonucleoprotein (RNP) delivery of CRISPR-Cas9, reduces off-target effects. The structural polyprotein Gag is typically used to package cargo into EVs, which nevertheless limits the EV packaging capacity. The present invention is an all-in-one EV delivery system termed NanoMEDIC (nanomembrane-derived extracellular vesicles for the delivery of macromolecular cargo). It is a transient EV-based CRISPR-Cas9 editing delivery system which ensures efficient genome editing in various cell types. |
 | Smart bench for ambulances and air-ambulances |
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The Department of Nursing of the University of Alicante has designed a new ambulances platform, which in addition to the current functions of the platforms allocating the stretchers in vehicles, provides the exact value of the weight of the patient, in real time, facilitating the calculation of precise doses of drugs, fluids, mechanical ventilation, etc. This platform has digitals sensors placed parallel along its lower side bars, connected to a digital transmitter and a screen via bluetooth or Wi-Fi. The design of the electronic device can be configured in a basic mode, just showing the weight of the patient allowing to health professionals to better calculate the correct doses of drugs, etc., by themselves; or its advanced mode, also detailing the exact dose of drugs, fluids, parameters of invasive mechanical ventilation, amount of energy, etc., automatically calculated with an integrated software. Companies interested in the commercial exploitation of the invention through a patent license agreement are sought. |
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