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 | Seeking Oral Care Solutions for Non-Bleach Whiteners |
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Breakthrough whitening benefits with daily use safety profile |
| | Seeking Respiratory Solutions and Technologies |
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Our preference is to find opportunities that are on-market, market-ready, or require limited development. Opportunities may consist of new product forms, packaging innovations, delivery technologies, or new products. |
| | Seeking Oral Care Solutions with Novel Cleaning Agents |
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Breakthrough cleaning benefits with daily use safety profile; Exploration of alternatives to flossing. Safe and effective removal of food and debris between teeth via chemical approach that would increase compliance and enhance the oral health benefits of driven by the flossing action, without having to floss. |
 | NanoMEDIC gene editing delivery system |
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Background Gene therapy holds great potential for the treatment of genetic diseases. However, delivery to specific tissues is still a major bottleneck. Although AAV-delivered CRISPR-Cas9 editing is being developed for multiple diseases, its therapeutic translation is hindered by the limited packaging capacity of viral particles and possible immune response to them. Moreover, AAV transgenes tend to be expressed for an extended period of time, which increases off-target mutagenesis risk. Extracellular vesicles (EV) is another option and, when combined with ribonucleoprotein (RNP) delivery of CRISPR-Cas9, reduces off-target effects. The structural polyprotein Gag is typically used to package cargo into EVs, which nevertheless limits the EV packaging capacity. The present invention is an all-in-one EV delivery system termed NanoMEDIC (nanomembrane-derived extracellular vesicles for the delivery of macromolecular cargo). It is a transient EV-based CRISPR-Cas9 editing delivery system which ensures efficient genome editing in various cell types. |
 | Shimmer3 Bioimpedance Monitor - Monitoring HR, respiration rate and depth, and the increase in fluid in the lungs to triage and remotely monitor Covid-19 patients |
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Managing the huge influx of patients in hospitals is one of the most critical challenges of the current COVID-19 pandemic. Shimmer’s Bioimpedance Monitor has the potential to help manage this challenge by monitoring HR, respiration rate and depth and the increase in fluid in the lungs to triage and remotely monitor patients. Background Bioimpedance, specifically across the lungs, has long been studied in Chronic Heart Failure (CHF) and Acute Respiratory Distress Syndrome (ARDS). This measurement provides useful indicators of respiration, including rate, volume, and fluid in the lungs. Because COVID-19 attacks the lungs, these measurements provide clear indications of the progression of the disease. This information can be used in many ways, potentially including: • Monitoring patients remotely at home to determine, if and when, they will need to be admitted to the hospital • Monitoring patients in a hospital to determine when they need more aggressive treatment (e.g., ventilators) • Enabling the earlier release of non-acute patients because of the ability to monitor at home • Adjusting the treatment depending on the rate of progression of disease |
 | Functional soy-based waxes |
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Airable Research Lab has developed a versatile soy-based wax platform designed to replace or complement petroleum-based waxes such as paraffin, polyethylene, and Fischer-Tropsch waxes. Our portfolio demonstrates broad expertise across functional wax classes and the ability to tailor properties for diverse industrial needs. |
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