Antimalarial Agent, Methods and Uses Thereof
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Antimalarial Agent, Methods and Uses Thereof
- Rui from NOVA University Lisbon
- From Portugal
- Responsive
- Patents for licensing
Summary of the technology
The present disclosure relates to compounds and compositions for the treatment of malarian diseases. The compounds comprise a class of halogenated alkyl-aromatic secondary metabolites, including hierridic C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The compounds comprise a halogen; C1-C6 alkyl, H, COCH3, COH, CO-alkyl, or CO-aryl; and a C3-C30 alkyl. In at least one embodiment, the compound is 3-chloro-4,6-dimethoxy-2-pentadecylphenol. The present disclosure also relates to methods of obtain the compounds from a solution comprising a cyanobacterium.
Background
In 2020, nearly half of the world’s population was at risk of malaria and according to the latest World Health Organization Malaria Report, there were 241 million cases of malaria infection, resulting in 627 000 deaths.
Over the last decade, there is a growing need for antimalarial agents, either for monotherapy or as multi-drug therapies as drug-resistant strains are emerging worldwide, in particular mefloquine and chloroquine resistant strains. Therefore, new agents able to kill the resistant malaria parasites are warranted.
Technology Overview
This technology relates to halogenated alkyl-aromatic secondary metabolites, in particular hierridin C from the cyanobacterium Cyanobium sp. LEGE 06113 and its application as an antimalarial and anticancer agent. Furthermore, this technology comprises the methods to obtain the compound from the Cyanobium sp. LEGE 06113 and to methods to chemically synthetize hierridin C and its derivatives under laboratory conditions.
The solution herein relates to processes used to obtain a new compound – hierridin C – from the cyanobacterial cultures, and to compounds sharing the same halogenated skeleton, and to its use in formulations for treating, preventing or inhibiting malaria in humans.
Further Details:
- Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria: J. Nat. Prod. 2019, 82, 393−402
Benefits
The advantage of this invention is that there is no strain of P. falciparum known to be resistant to halogenated alkyl-aromatic secondary metabolite, in particular hierridin C and its derivatives. This is relevant as death by malaria is almost exclusively caused by P. falciparum.
The hierridin C is a natural product and can be obtained from a renewable, photoautotrophic source by mass culturing in the laboratory or open ponds or alternatively it may be chemically synthetized.
Applications
The hierridin C is a new antimalarial agent, which can be used to treat malaria, one of the most prevalent and life threatening infectious diseases in the developing world.
Current development status
Experimental technologies
Intellectual property status
- Patent already applied for
- Patent application number :WO2016207869
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016207869
- Granted Patent
- Patent application number :EP3313807
https://worldwide.espacenet.com/patent/search/family/056497812/publication/EP3313807B1?q=WO2016207869
- Granted Patent
- Patent application number :US10287228
https://worldwide.espacenet.com/patent/search/family/056497812/publication/US10287228B2?q=WO2016207869
Related Keywords
About NOVA University Lisbon
Founded in 1973, NOVA University Lisbon encompasses nine schools that offer a wide variety of degrees in all areas of knowledge and constitute an incontestable cultural, artistic, academic, and technological resource. NOVA has a strong tradition of work in areas of innovation, with corresponding outcomes in the economy, services, and in extracurricular training, establishing important protocols with its peers, both nationally and internationally.
Innovation and Entrepreneurship are embedded in NOVA’s culture, being widely promoted within the University’s ecosystem as a way of fostering knowledge transfer and transforming research results into social and economic value, focuses particularly on promoting a knowledge-based and high-impact value creation activity, through collaborations with industry and society.
The NOVA Impact office contributes to the University’s societal benefit by working with academics, researchers and students to apply and maximize the impact of their expertise and research, to foster knowledge transfer and transform innovative results in social and economic value.
We support and develop initiatives that add social or economic value, based on the knowledge produced at NOVA, promoting a knowledge-based and high-impact value creation activity through collaborations with society and industry. We set up new programs to encourage entrepreneurship and new cross-cutting initiatives to strengthen collaboration with businesses.
We help NOVA innovators and entrepreneurs to develop their ideas for the benefit of society, the economy, themselves, and the University.
Typical activities and support include the IP protection, development and commercialization of ideas/technology, entrepreneurship training, new company or social enterprise creation, and liaising with industry or other organizations to partner up towards impact-driven projects and initiatives.
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