Pathogenic control of apoptosis
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Technology Offer
Pathogenic control of apoptosis
- CSIR
- From South Africa
- Responsive
- Innovative Products and Technologies
Summary of the technology
Measuring cellular response to infection using novel reporter markers.
Applications
Measuring cellular response to infection using novel reporter markers
Technology Field
Biotechnology
Business Opportunity
Investment for further technology development and conduct relevant trials
Technology Description
Monitoring the cellular response to infection using a fluorescent reporter, single molecule FISH and immunofluorescent labeling, revealed that HIV1 masks DNA damage and orchestrates a complex dysregulation of lincRNAp21. By sequestering HuR in the nucleus following proviral integration, HIV1 enables lincRNAp21 degradation.
Benefits & Advantages
very specific report model to measure response to infection at a cellualar level
Inventors
Dr Janine Scholefield Dr Musa Mhlanga Jerolen Naidoo Dr Sam Barichievy
Related Keywords
About CSIR
The Council for Scientific and Industrial Research, commonly known as the CSIR, is a world-class African research and development organisation established through an Act of Parliament in 1945. The CSIR undertakes directed, multidisciplinary research and technological innovation that contributes to the improved quality of life of South Africans.
The CSIR’s shareholder is the South African Parliament, held in proxy by the Minister of Higher Education, Science and Innovation.
CSIR vision
We are accelerators of socio-economic prosperity in South Africa through leading innovation.
CSIR mission
Collaboratively innovating and localising technologies while providing knowledge solutions for the inclusive and sustainable advancement of industry and society.
CSIR values
CSIR values statement:
Our beliefs, principles and the impact we wish to make to improve the quality of life of South Africans are EPIC. Team CSIR pursues Excellence, celebrates People, personifies Integrity, and welcomes Collaboration.
Our mandate
“The objects of the CSIR are, through directed and particularly multi-disciplinary research and technological innovation, to foster, in the national interest and in fields which in its opinion should receive preference, industrial and scientific development, either by itself or in co-operation with principals from the private or public sectors, and thereby to contribute to the improvement of the quality of life of the people of the Republic, and to perform any other functions that may be assigned to the CSIR by or under this Act.”
(Scientific Research Council Act 46 of 1988, amended by Act 71 of 1990)
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