The hyperpolarization-activated cyclic nucleotide-gated #HCN channels are voltage-gated ion channels that play a vital role in regulating the activity of many cell types. Extensive research has shown that HCN channels may be a valuable target for the treatment of a number of neurological disorders.
The Hyperpolarization-Activated Cyclic Nucleotide Gated Channel Blocker Library by Otava Chemicals https://bit.ly/3CBSKDK may be the perfect basis for antianginal, antiarrhythmic, neuropathic, etc. research and drug discovery projects.
The library was designed by pharmacophore screening of Drug-like Green Collection against two ligand-based pharmacophore models. The models were built based on well-known HCN channel blockers.
◾This library contains 634 compounds with predicted HCN channels blocking activity and ready for prompt delivery.
◾ Reactive, pan-assay interference (PAINS), redox-active and aggregator compounds were removed from the library.
◾ Cherry-picking is available.
◾ Supplied as dry powder or DMSO solution.
For ordering and additional information, please email us to info@otavachemicals.com.
Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.
Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.
We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.
Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.
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