The diverse etiopathogenesis and the absence of biomarkers that can be used in the diagnosis of neurodegenerative and neurological diseases make difficult a correct diagnosis and treatment. Achieving a biomarker that helps to make the correct diagnosis and select the appropriate treatment for each patient in the less possible time is crucial for the patient’s complete recovery.
The present invention is focused on the provision of a panel of biomarkers elected among LRP proteins of fragments thereof.
It is proposed an in vitro method for the diagnosis or prognosis of neurodegenerative disorders based on new fragments of LRP (LRP1 and LRP2) in a biological sample, wherein if the level of expression of the concentration of the LRP fragment is significantly lower or higher (depending on the neurodegenerative disorder) as compared with the level measured in healthy controls, this is indicative that the subject is suffering the disease or has a bad prognosis.
The proposed biomarker and a new nanosensor for the detection of the fragments in biological samples through Surface-enhanced Raman Spectroscopy (SERS) technology for the diagnosis of Major Depression in a early stage have been validated in a cohort of patients.
Applications
Use in medical field for the diagnosis and prognosis of neurodegerative disorders: major depression, multiple sclerosis or Alzheimer disease.
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