The retinoid X receptors (RXRs) are ligand-activated transcription factors heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of physiological processes. The invention relates to novel enantiomer compounds which are derivatives of dihydroretinoic acid, their stereoselective synthesis, to pharmaceutical compositions containing the same and to the use in the treatment of diseases.
Retinoid X receptors (RXRs) are ligand-activated transcription factors controlling a variety of physiological processes. The invention relates to novel enantiomer compounds which are derivatives of dihydroretinoic acid, their stereoselective synthesis, to pharmaceutical compositions containing the same.
In the context, inventors focused on novel endogenous retinoid, which is detectable in mice at concentration sufficient to displays RXR agonistic activities in vitro and in vivo.
Innovative method for stereoselective synthesis of 9-cis-13,14-dihydroretinoic acid and its ethyl esters.
Applications
The compounds and/or the pharmaceutical compositions according to the invention may be used in a therapeutic method: are especially useful in the prevention and/or treatment of short-term memory impairment and are particularly useful in improving working memory performance or reducing working memory loss. In addition, the compounds of the invention might be used as a nutritional or dietary supplement, in a functional food composition, in a dietary supplement composition or in a nutraceutical composition. Methods of introduction include but are not limited to intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, intraocular, epidural and oral routes.
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