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A highly specific and sensitive anti-Importin b1 (KPNB1) monoclonal antibody. The mAb recognizes an epitope
comprising residues 301-320 of human KPBN1 and is highly specific for cytoplasmic KPNB1 in diverse
applications.
Description
Importin b1 (KPNB1) is a nucleocytoplasmic transport factor with critical roles in both cytoplasmic and
nucleocytoplasmic transport, hence there is keen interest in its characterization and subcellular interactomes.
However, the current efficiency of proximity-dependent biotin identification (BioID) in detecting importin complex
cargos is very limited. Therefore, Prof. Fainzilber and his team generated a highly specific and sensitive antiKPNB1 monoclonal antibody, which enables Biotinylation by Antibody Recognition (BAR) analysis of importin b1
interactomes. The monoclonal antibody recognizes an epitope comprising residues 301-320 of human KPBN1, and
strikingly is highly specific for cytoplasmic KPNB1 in diverse applications, with little or no reaction with KPNB1 in
the nucleus. BAR with this novel antibody revealed numerous new interactors of importin b1, expanding the KPNB1
interactome to cytoplasmic and signaling complexes that highlight potential new functions for the importins complex
beyond nucleocytoplasmic transport. Additional data is available on Biorxiv https://www.biorxiv.org/content/10.1101/2022.03.23.485495v1 [1]
Yeda ("Knowledge" in Hebrew) Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science (WIS) and is the second company of its kind established in the world.
WIS is one of the world’s leading multidisciplinary basic research institutions in the natural and exact sciences. It is located in Rehovot, Israel, just south of Tel Aviv. It was initially established as the Daniel Sieff Institute in 1934, by Israel and Rebecca Sieff of London in memory of their son Daniel. In 1949, it was renamed for Dr. Chaim Weizmann, the first President of the State of Israel and Founder of the Institute.
Yeda initiates and promotes the transfer to the global marketplace of research findings and innovative technologies developed by WIS scientists. Yeda holds an exclusive agreement with WIS to market and commercialize its intellectual property and generate income to support further research and education.
Since 1959 Yeda has generated the highest income per researcher compared to any other TTO worldwide. Weizmann has generated a number of groundbreaking therapies, such as Copaxone, Rebif, Tookad, Erbitux, Vectibix, Protrazza, Humira, and recently the CAR-T cancer therapy Yescarta.
Yeda performs the following activities:
◣ Identifies and assesses research projects with commercial potential.
◣ Protects the intellectual property of WIS and its scientists.
◣ Licenses WIS' inventions and technologies to industry.
◣ Establishes new Startup companies based in WIS Intellectual Property
◣ Channels funding from industry to research projects.
Our portfolio covers a broad spectrum of the natural sciences, including:
◣ Agriculture and Plant Genetics, including Bio-fuels
◣ Chemistry and Nanotechnology
◣ Environmental Sciences and Solar Energy
◣ Mathematics and Computer Science
◣ Medical Devices
◣ Pharmaceuticals and Diagnostics
◣ Physics and Electro-Optics
◣ Research Tools
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