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Three new biomarkers for the prognosis, stratification and cancer monitoring have been identified: PCA3, MRC2, and S100A4. These biomarkers could be detected by non-invasive methods, such as liquid biopsy, and be used as a component for kits and devices with the same purpose.
Prostate cancer is one of the most common death causes worldwide, and one of the most frequently diagnosed tumours in males in Spain. In spite of that, diagnosis tools for their detection are lacking and there are no adequate genetic biomarkers: nowadays, PSA is the most common biomarker, despite the high percentage of false positives and false negatives.
Regarding treatment choice, there are no tools that can determine which treatment is the most effective for each patient. With it, the standard treatment is androgen deprivation therapy (ADT), which causes many hormone resistance cases. Despite existing a good initial response, after 18-24 months of ADT therapy, prostate cancer progresses to the castration resistant prostate cancer (CRPC) phase, which has 16 to 18 months survival rate.
To overcome that, three new genetic biomarkers PCA3, MRC2, and S100A4 have been identified. They can be used to detect, classify and/or prevent prostate cancer. PCA3 non-coding RNA is specific of prostatic tissue and is overexpressed early in prostate cancers; an overexpression of MRC2 indicates a higher extracellular matrix remodelling rate, which will ease further metastasis; and S1004A gene is overexpressed when cancer is more aggressive and metastasis has already started.
In addition, the detection of these biomarkers can be performed using non-invasive methods, such as liquid biopsy, and would be ideal for the development of kits and devices for the prevention, diagnosis and stratification of prostate cancer.
ADVANTAGES AND BENEFITS
Current development status
Laboratory prototypes
Applications
Oncology
Health
Diagnostic
Biotechnology
Desired business relationship
Patent licensing
Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....
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