The invention is a proposal for innovative biotechnology for the targeted mucosa and transmucosal delivery and/or controlled release of active pharmaceutical ingredients for various therapeutic applications when on-demand drug administration is needed. The biodevice is also composed by a biosensor system that may enable extraction of mucosa and submucosa body fluids monitoring systems to identify the biological characteristics related to several diseases.
The present invention proposes a removable drug delivery system combining the drug-delivery operation principle applied to mucosa drug-release from multiple reservoirs. This invention takes advantage of the electrical conductivity properties of graphene and of its great potential to operate as a drug- and electron-carrier to create a programmable drug delivery. These properties provide a miniaturized tunable drug-delivery system, capable of finely regulating rate, timing and speed of drug release. The role of graphene as drug carrier for drug delivery system has been widely explored in the past: the present device is capable of a controlled retainment and release of drugs for extended periods of time, as well as of an immediate release for quick action of drugs at different doses on an as-needed basis. The present innovation combines immediate-release system and zero-order release system improving pharmacokinetics of mucosa drug release.
Properly loaded, the device may be applied for the therapeutic treatment of: gastrointestinal, genitourinary and psychiatric disorder, neurological disorder and nutritional deficiency, including but not limited to adrenal insufficiency, allergy, anxiety disorder, asthma, attention-deficit hyperactivity disorder, bipolar disorder, chronic and acute pain, chronic bronchitis, chronic obstructive pulmonary disease, chronic obstructive pulmonary disease, congestion, cramp, cyclic vomiting syndrome, dementias, dependence syndrome, diabetes mellitus, epilepsy, fever, genitourinary disorder, hypercholesterolemia, hormonal imbalance, hyperglycaemia, hypersalivation, hypertension, hypotension, hypothyroidism, infectious disease, inflammatory diseases, menopause, menstrual regulation, migraine, mood disorders, musculoskeletal pain, nausea, neoplasms, obesity, Parkinson's disease, pulmonary disease, respiratory disease, sexual dysfunction, sleep disorder, smoking cessation, vaginal diseases, vomiting.
Advantages:
Tunable drug-delivery system for both short- and long-term release even altering drug release schedule in real-time, constantly operating on a time-scale of a few minutes to hours
Electrical-, light- and magnetic-induced drug-release exploiting graphene properties and inducing an active compound release thanks to its drug- and electron-carrier properties
The properties of graphene as a drug-carrier system offer the peculiar ability to conjugate different drugs in a single graphene sheet, promoting a synergy and versatility of operation controlling additive effects of distinct pharmaceutical compounds
Due to graphene electrical and nanocarriers properties, the electrical currents generated by the microprocessor may break ionic bonds of the drug-conjugated graphene compound, promptly releasing the drug and expelling it out of the reservoir, thus enhancing in situ availability
Founded in 1978, SISSA Scuola Internazionale Superiore di Studi Avanzati of Trieste, Italy, is a leading institute for research and postgraduate training on the national and international stage. It is one of the six schools of excellence in Italy.
The aim of the School is to promote the development of scientific research and intellectual culture, all the while preparing young graduate students for advanced research, both pure and applied. The School was initially active in the so-called “hard sciences”, before expanding its range of activities to comprise new fields such as Neuroscience, Structural-Functional Genomics, Data Science and Science Communication. Research and training activities are grouped within three main areas: Physics, Mathematics and Neuroscience.
Besides its traditional pillars (Higher education and Research), in the recent years SISSA has been constantly working to promote new activities and initiatives focused on fostering the societal and economic development of the local Territory, the so called Third Mission to promote innovation and knowledge transfer.
For more information on SISSA innovation technologies and know-how, please contact us at valorisation@sissa.it
Create your free account to connect with SISSA and thousands of other innovative organizations and professionals worldwide
Send a request for information
to SISSA
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
