Treatment of Autoimmune Diseases by Modulating Bregs
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Technology Offer
Treatment of Autoimmune Diseases by Modulating Bregs
- Yeda
- From Israel
- Responsive
- Patents for licensing
Summary of the technology
Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission.
Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.
Applications
• Diagnosis of CLL
Advantages
• Very specific to malignant B cells
• Diagnosis, and therefore treatment, can be made at early stages of the
disease
Technology's Essence
B cells taken from CLL patients have a high level of the protein CD84. Stimulation of CD84 upregulates the survival of B-CLL. However, inhibition of CD84 activity with a blocking antibody downregulates the expression of another protein which controls B-CLL survival, thus inducing cell death. Therefore, the present invention reveals CD84 as a regulator of B-CLL survival.
Intellectual property status
- Granted Patent
- Patent application number :USA Granted: 10,611,839 USA Granted: 9,109,029 USA Granted: 10,329,347 USA Granted: 10,828,318 USA Granted: 8,686,121 USA Granted: 10,066,014
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About Yeda
Yeda ("Knowledge" in Hebrew) Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science (WIS) and is the second company of its kind established in the world.
WIS is one of the world’s leading multidisciplinary basic research institutions in the natural and exact sciences. It is located in Rehovot, Israel, just south of Tel Aviv. It was initially established as the Daniel Sieff Institute in 1934, by Israel and Rebecca Sieff of London in memory of their son Daniel. In 1949, it was renamed for Dr. Chaim Weizmann, the first President of the State of Israel and Founder of the Institute.
Yeda initiates and promotes the transfer to the global marketplace of research findings and innovative technologies developed by WIS scientists. Yeda holds an exclusive agreement with WIS to market and commercialize its intellectual property and generate income to support further research and education.
Since 1959 Yeda has generated the highest income per researcher compared to any other TTO worldwide. Weizmann has generated a number of groundbreaking therapies, such as Copaxone, Rebif, Tookad, Erbitux, Vectibix, Protrazza, Humira, and recently the CAR-T cancer therapy Yescarta.
Yeda performs the following activities:
◣ Identifies and assesses research projects with commercial potential.
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◣ Channels funding from industry to research projects.
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