Acquisition of Multidimensional NMR Spectra in a Single Scan
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Acquisition of Multidimensional NMR Spectra in a Single Scan
- Yeda
- From Israel
- Responsive
- Patents for licensing
Summary of the technology
Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovering new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans, in contrast to one-dimensional spectroscopic methods. Therefore, rapidly changing chemical systems and in vivo clinical measurements such as magnetic resonance imaging (MRI) are not suited for this technique. The current technology allows the acquisition of multidimensional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images. This technique could be applied to existing NMR/MRI devices.
The Need
NMR and MRI are costly devices due to their inner superconductive magnet. Along with their high cost, the long acquisition time needed for high-resolution spectra/images made these instruments the bottleneck for structure solving and in-vivo diagnostics (for multidimensional NMR and MRI, respectively). Shortening the time needed for each measurement will enable higher measurement capacities with better resolution.
The Solution
While regular multidimensional NMR acquisition is based on many experiments which are being conducted in different scans one by one, in this technique, all the experiments are performed in parallel in the same scan. This method allows obtaining high-resolution multidimensional NMR spectra after a single scan[i].
[i] L. Frydman, T. Scherf and A. Lupulescu, Proceedings of the National Academy of Sciences Dec 2002, 99 (25) 15858-15862; DOI: 10.1073/pnas.252644399
Technology Essence
This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image of a full multidimensional spectrum from the entire sample.
Applications and Advantages
Applications
In vivo diagnostics
- High-throughput proteomics/metabonomics
- NMR of unstable chemical systems
Metabolic dynamics
- High-resolution NMR in tabletop systems
- Extensions to non-MR spectroscopies
Advantages
- Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
- Compatible with the majority of multidimensional pulse sequences
- Can be implemented using conventional NMR and MRI hardware
[1] L. Frydman, T. Scherf and A. Lupulescu, Proceedings of the National Academy of Sciences Dec 2002, 99 (25)
15858-15862; DOI: 10.1073/pnas.252644399
Intellectual property status
- Granted Patent
- Patent application number :USA Granted: 6,873,153 USA Granted: 7,271,588 USA Granted: 7,944,206 USA Granted: 10,794,980
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About Yeda
Yeda ("Knowledge" in Hebrew) Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science (WIS) and is the second company of its kind established in the world.
WIS is one of the world’s leading multidisciplinary basic research institutions in the natural and exact sciences. It is located in Rehovot, Israel, just south of Tel Aviv. It was initially established as the Daniel Sieff Institute in 1934, by Israel and Rebecca Sieff of London in memory of their son Daniel. In 1949, it was renamed for Dr. Chaim Weizmann, the first President of the State of Israel and Founder of the Institute.
Yeda initiates and promotes the transfer to the global marketplace of research findings and innovative technologies developed by WIS scientists. Yeda holds an exclusive agreement with WIS to market and commercialize its intellectual property and generate income to support further research and education.
Since 1959 Yeda has generated the highest income per researcher compared to any other TTO worldwide. Weizmann has generated a number of groundbreaking therapies, such as Copaxone, Rebif, Tookad, Erbitux, Vectibix, Protrazza, Humira, and recently the CAR-T cancer therapy Yescarta.
Yeda performs the following activities:
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