Our technology is intended to degrade and inactivate xenobiotics such as antibiotics in aqueous media using grafted enzymes. We are able to graft at least one enzyme onto a solid support in order to stabilise it and enhance its longevity. Excellent degradation rates have been obtained on antibiotics using New-Delhi metallo-β-lactamase 1, laccases extracted from Pleurotus ostreatus and β-lactamases extracted from Pseudomonas aeruginosa. The enzymes were grafted on floating Polyethylene carriers that can be put into action in and moving bed reactors.
Background:Antibiotic resistance is an increasing problem worldwide. It stems essentially from inadequate overuse of these drugs for human as well as animal health care. Antibiotics are found in significant amounts in wastewater, especially if this latter contains hospital effluents. Decreasing the emission of antibiotics into the aquatic ecosystems is key to prevent dissemination of antibiotics and the subsequent selection and dispersal of antibiotic resistance genes in these ecosystems. The wastewater treatment plants should therefore be equipped with technologies allowing the elimination of pharmaceuticals, especially antibiotics.
Benefits:
The main benefits of our technology is the specificity and high degradation efficiency of the fixed enzymes compared to other conventional antibiotic degradation systems. The technology is not generating dangerous by-products and can be easily installed in wastewater treatment plants, in moving bed reactors.
The patent is quite strong in the sense that it allows to prevent a competitor to graft enzyme onto a solid support (like onto a Kaldnes in a moving bed carrier).
Applications:
The technology can especially be incorporated in decentralised wastewater treatment units targeting health care infrastructures (hospitals, retirement houses) where antibiotics are intensively used.
Opportunity:
As European legislation is moving on the reduction of pharmaceuticals in aquatic ecosystems, we are searching for industrial partners which want to position on the emerging market of pharmaceutical treatment at the source.
Opportunity / Seeking:
We are searching for industrial partners active in the design of wastewater treatment plants in order to demonstrate at the plant scale the performance of our technology.
Desired business relationship
Technology development
The Luxembourg Institute of Science and Technology (LIST) is a mission-driven Research and Technology Organisation (RTO) active in the fields of materials, environment and IT.
LIST develops competitive and market-oriented product/service prototypes for public and private stakeholders, and works across the entire innovation chain: fundamental/applied research, incubation, transfer of technologies.
By transforming scientific knowledge into technologies, smart data and tools, LIST empowers citizens in their choices, public authorities in their decisions and businesses in their strategies.
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