THERAPEUTIC TREATMENT AGAINST NEURODEGENERATIVE PRION DISEASES
Patents for licensing
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Technology Offer
THERAPEUTIC TREATMENT AGAINST NEURODEGENERATIVE PRION DISEASES
- SISSA
- From Italy
- Responsive
- Patents for licensing
Summary of the technology
To date, despite numerous active efforts, there are no drugs available for the cure of the neurodegenerative diseases collectively referred as prion and prion-like disorders. Symptomatic treatment is the only available option, including the administration to patients of antipsychotics, such as quetiapine and clonazepam, to treat myoclonus, and of selective serotonin re-uptake inhibitors (SSRIs) to treat depression. Indeed, through this invention, we are presenting a new class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines, thereby representing a new therapeutic treatment against prion and prion-like diseases. The development of specific inhibitors of SERPINA3 with an activity in the nanomolar range is expected. The characterization of structural models of the binding of the small molecules with the protein should allow the identification of novel inhibitors with improved potency.
POSSIBLE APPLICATIONS
- Prion diseases treatment;
- Use in pharmaceutical compositions as serpina3 inhibitors
ADVANTAGES
- Potentially effective therapy for the treatment of prion diseases;
- Valid alternative to the administration of antipsychotics;
- It allows the identification of new inhibitors for neurodegenerative diseases;
- Approved reduction in the concentration of infectious agents
Intellectual property status
- Granted Patent
- Patent application number :EP18170092
https://register.epo.org/application?number=EP18170092&tab=main
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About SISSA
Founded in 1978, SISSA Scuola Internazionale Superiore di Studi Avanzati of Trieste, Italy, is a leading institute for research and postgraduate training on the national and international stage. It is one of the six schools of excellence in Italy.
The aim of the School is to promote the development of scientific research and intellectual culture, all the while preparing young graduate students for advanced research, both pure and applied. The School was initially active in the so-called “hard sciences”, before expanding its range of activities to comprise new fields such as Neuroscience, Structural-Functional Genomics, Data Science and Science Communication. Research and training activities are grouped within three main areas: Physics, Mathematics and Neuroscience.
Besides its traditional pillars (Higher education and Research), in the recent years SISSA has been constantly working to promote new activities and initiatives focused on fostering the societal and economic development of the local Territory, the so called Third Mission to promote innovation and knowledge transfer.
For more information on SISSA innovation technologies and know-how, please contact us at valorisation@sissa.it
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