SUBSTRATES FOR THE CULTURE AND STIMULATION OF NEURAL CELLS
Patents for licensing
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Technology Offer
SUBSTRATES FOR THE CULTURE AND STIMULATION OF NEURAL CELLS
- SISSA
- From Italy
- Responsive
- Patents for licensing
Summary of the technology
This project includes the development of a new generation of sensors and electrodes based on nanotechnological materials of neural interfacing. The aims is to design and produce a prototype of an active implant that could work directly at the spinal-cord level. This implant will allow restoring the transmission of electrical signals in injured axon tracks of the spinal cord. Due to some limitations, electrodes are currently placed at the brain to detected electric potentials, or at the muscles to trigger functional electrical stimulation (FES).
The research proved that the nano-structure of these electrodes can offer an enhanced adhesion as well as efficiency when compared to conventional FES electrodes. The main object of the project is to develop a cost-effective, biocompatible and easy to use. The use of the substrate of the invention wherein its textured surface has a plurality of protrusions, it presents improved interaction with cells and allows the growing of active cell cultures on it.
POSSIBLE APPLICATIONS
- The invention could be, for example massively used by biotech and medical industries to fabricate novel substrates to:
- Improve cell/substrate adhesion to electrodes;
- Create new device to grow cells for 3D biotech studies;
- Electrically stimulate laboratory cell cultures for biotech studies.
ADVANTAGES
- Low cost thanks to the hot-pressing procedure of the polymeric surface for nano-structuring;
- High performance;
- Highly controllable substrates;
- Manufacturing procedure useful in various applications.
Intellectual property status
- Granted Patent
- Patent application number :EP19382889.4
https://register.epo.org/application?number=EP19382889&tab=main
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About SISSA
Founded in 1978, SISSA Scuola Internazionale Superiore di Studi Avanzati of Trieste, Italy, is a leading institute for research and postgraduate training on the national and international stage. It is one of the six schools of excellence in Italy.
The aim of the School is to promote the development of scientific research and intellectual culture, all the while preparing young graduate students for advanced research, both pure and applied. The School was initially active in the so-called “hard sciences”, before expanding its range of activities to comprise new fields such as Neuroscience, Structural-Functional Genomics, Data Science and Science Communication. Research and training activities are grouped within three main areas: Physics, Mathematics and Neuroscience.
Besides its traditional pillars (Higher education and Research), in the recent years SISSA has been constantly working to promote new activities and initiatives focused on fostering the societal and economic development of the local Territory, the so called Third Mission to promote innovation and knowledge transfer.
For more information on SISSA innovation technologies and know-how, please contact us at valorisation@sissa.it
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