SARS-CoV-2 Main Protease Targeted Library
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Technology Offer
SARS-CoV-2 Main Protease Targeted Library
- Taras from Otava Research Institute
- From Ukraine
- Responsive
- Innovative Products and Technologies
Summary of the technology
OTAVAchemicals and Montana Molecular are providing a complete solution for COVID-19 drug discovery that combines verified compound libraries with functional cell-based assays and drug development services.
Details of the Technology Offer
For many viruses, the protease enzyme is responsible for the proteolytic maturation of the poly-protein essential for the viral replication and transcription. The main protease of SARS-CoV-2 highlights as an important drug target because it is dissimilar to human proteases.
SARS-CoV-2 Main Protease Targeted Library has been designed with receptor-based virtual screening using crystal structure (PDB ID: 6LU7) of SARS-CoV-2 main protease. The overall procedure included accurate flexible docking of Drug-like Green Collection into protease cleavage site. Final selection of compounds was made with inspection of the enzyme active site’s crucial structural determinants for ligand binding, docking scores and intermolecular hydrogen bonds with the key active site’s amino acid residues.
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About Otava Research Institute
Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.
Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.
We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.
Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.
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