Metallobio are developing novel antimicrobial additives. The additives modular synthesis makes this platform technology applicable in many different fields. The additives exhibit broad-spectrum activity against a range of planktonic and biofilm forming bacteria including World Health Organisation Priority Pathogens. Metallobio have incorporated these additives into a range of materials including polymers and commercial latexes. The antimicrobial materials have good durability and a high antimicrobial efficacy.
Detailed description
Metallobio have developed a novel set of antimicorbial additives. The modular synthesis of the additives means a range of these complexes can be developed, and their properties altered to suit different applications. The additives themselves are more active than clinically available antibiotics on planktonic cells and biofilm-forming bacteria and they retain this high activity in multi-drug resistant strains. The additives have a multi-modal mechanism of action including a novel target and have exhibited a strong efficacy and low toxicity in vitro, ex vivo and in vivo.
Given the additives high antibiofilm activity the possibility of incorporating the additives into antimicrobial materials has been explored, these materials include polymers and commercial latexes. The materials have exhibited high activities against bio-film forming bacteria including the World Health Organisation critical priority pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii. Metallobio have explored the adhesion of these coatings to a range of materials and foresee use in medical applications such as medical device coatings to prevent bacterial biofilm formation. Additionally, Metallobio are exploring the use of these materials in non-medical settings for example textiles and food packaging.
Intellectual property status
Patent already applied for
Patent application number : PCT/GB2020/050875
Where : Regional/National Phase entry is planned fro Australia, Brazil, Canada, China, Europe, India, Japan, Russia, South Africa, South Korea, The USA, Brazil, Mexico, Argentina and Singapore
Current development status
Working prototypes
Desired business relationship
Patent licensing
Joint ventures
Technology development
New technology applications
Metallobio are developing novel antimicrobial additives for medical and non-medical materials. Metallobio are a University of Sheffield spin-out company, based in Sheffield and have 5 employees.
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