RNA is essential for transcriptional regulation, translational regulation, protein function, and catalysis, responsibilities that have classically been reserved for proteins. It also highlights the potential of targeting RNA for treatment of a multitude of diseases including bacterial/viral infection and cancer
RNAs can form well-defined secondary structures, such as double helices, hairpins, bulges, internal loop, stems, which offer structural basis for designing therapeutic agents. These structural features have been taken into account in the design of our RNA Targeted Library (2542 compounds in total), which is a special screening library that contains compounds with predicted RNA interaction activity based on different types of secondary structures.
The compounds have been selected with Bayesian models using most active template compounds from [2]. Separately, we collected a training set of miRNA targeted compounds taken from PubChem database.
Two models, one based on the FCFP6 fingerprints and the other on the ECFP6, formed the basis of the training kits. LogP, molecular weight, number of hydrogen donors and acceptors, number of rotating bonds, number of rings and molecular polar surface area were used by us to build more accurate models.
The best compounds were selected after screening the OTAVAchemicals Drug-Green drug collection.
Therefore, all compounds from the RNA target library correspond to the physical and structural parameters of typical RNA target compounds and contain important molecular fragments.
It contains only drug-like compounds, which provides an excellent basis for research on post-transcriptional regulation of genes, projects for the detection of antitumor, antiviral and antibacterial drugs.
Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.
Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.
We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.
Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.
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