Researchers from the University of Granada and the Andalusian Health Service have developed a new biomaterial based on echinoderm ossicles and an in vitro method of preparing it for bone lesions treatment. The present invention is highly biocompatible and exhibits in vivo functionality, which represents an improvement in bone tissue regenerative medicine, with potentially better results in terms of bone regeneration and repair than other currently available materials.
Hard tissue injuries, especially bone, are very difficult to treat due to their special biological and functional characteristics. Most of the biomaterials currently available for the treatment of bone injuries have very poor biocompatibility and functionality in vivo.
To date, the treatments and materials used in severe injuries to human bone result in very slow biointegration in the bone and low success rates. Therefore, the search for new highly biocompatible materials for use in the repair of bone defects is a priority in the field of trauma.
In this context, researchers have developed a process for obtaining and using a new biomaterial employing for the first time dermal ossicles from Holothuria echinoderm. These calcified microstructures are synthesized by one or more cells of the animal, which adhere closely to the surface of the ossicle. For this reason, the surface of the ossicles is potentially highly biocompatible, which supports its clinical use as an inducing agent for bone regeneration.
The results obtained from the ex vivo and in vivo biocompatibility and efficacy studies confirm the proper biointegration process of the biomaterial, with the absence of signs of necrosis, tumor, infection, hemorrhage or rejection. Furthermore, greater bone repair and regeneration are demonstrated in bone defects treated with holothurian ossicles.
ADVANTAGES AND BENEFITS
Current development status
Experimental technologies
Applications
Regenerative medicine
Tissue engineering
Traumatology
Desired business relationship
Patent licensing
Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....
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