The use of melatonin is proposed as a co-treatment of tumours and to alleviate the adverse side effects derived from other more invasive treatments. Melatonin administration by intratumoral injection and in high doses promotes the activation of mitochondrial function, ultimately causing the death of cancer cells.
Current cancer treatments are based on the use, isolated or combined, of surgery, chemotherapy and/or radiotherapy. These therapies are associated with the development of adverse side effects in the patient in the short and long term. Some of the most common types of cancer (such as head and neck squamous cell carcinoma, HNSCC) have an increasing incidence and mortality in the population, that together with other limitations, such as the absence of an early diagnosis that prevents the development of the disease towards more advanced stages and drug resistance, reveal the urgency to find and identify new therapeutic agents with greater efficacy and less toxicity.
Our technology presents a pharmaceutical composition that comprises a high dose of melatonin which, after intratumoral administration, is useful in tumor treatment. In high concentrations, melatonin exerts an oxidative effect, and increases the production of free radicals through the activation of mitochondrial function and, as a consequence, by activating apoptotic mechanisms in tumor cells.
The use of this composition is a treatment method that leads to the elimination of the tumor, the time increase of the disease progression and survival rate, as well as allowing long-term disease control.
ADVANTAGES AND BENEFITS:
Applications
Cancer treatment
Desired business relationship
Patent licensing
Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....
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