The variety of tools to mimic a biological membrane as a functional barrier in fundamental research and biotechnological application are available. One of them – tethered bilayer lipid membranes (tBLM) – is the most relevant model with a controllable sub-membrane reservoir. Our technology based on anchoring of lipid-like compounds, enables the production of the stable artificial lipid membranes in a quicker and convenient way. This platform is more suitable for electrochemical approach while also mimics a cell plasma membrane in in vitro experiments better.
PROPOSAL
A broad spectrum of tBLM architecture allows to mimic different cell membranes (blood cells, neurons, bacterial, etc.) or investigate particular biological/biochemical processes in various biological fluids such as blood, urine or saliva.
APPLICATION
The tBLM-based biosensoric system might be utilized in point of care diagnostics, drug discovery and other pharmaceutical research.
INTELLECTUAL PROPERTY
Patent: LT2015 080. Applicant: Vilnius University.
INVENTORS
Dr. Gintaras Valinčius, electrochemistry impedance spectroscopy method development; dr. Rima Budvytytė,misfolded proteins in neurodegenerative disease development; dr. Tadas Ragaliauskas, lipid membrane models development; dr. Marija Jankunec, visualisation and nanomechanical properties of proteins interaction with lipid bilayer by AFM; PhD student Tadas Penkauskas, practical and theoretical development of lipid–based EIS biosensor.
PUBLICATIONS
Ragaliauskas et al. (2017) Biochim Biophys Acta Biomembr., 2017, 1859(5):669-678
Ragaliauskas et al. (2019) Sci Rep., 2019, 9(1):10606
Current development status
Laboratory prototypes
Vilnius University is the largest Lithuanian higher education and research institution. We are open for collaborative research, contract research or any cooperation activities with partners from business and public organizations. Multidisciplinary approach on R&D activities at Vilnius University provides unique opportunity to incorporate methodologies, perspectives, data and concepts from all scientific fields – biomedical, physical sciences, technologies, social sciences and humanities. We believe that the right mix of shared intentions with our partners and clients, outstanding teams of university researchers and open access to modern R&D infrastructure deliver remarkable solutions that can change organizations, markets and society in general.
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