Our research involves the modification of a recently patented molecule that contains L-3,4-dihydroxyphenylalanine (DOPA) and other bonding peptides to increase osseointegration on metal surfaces, particularly titanium. Lab results show that when coated with this molecule, titanium surfaces showed increased signs of bio-compatibility, which is backed up by published scientific research. The technology has the potential of improving osteosynthesis and orthopedic implants, as well as many other types of surgical implants. The BBZ is looking for licensing, joint R&D, or ownership opportunities regarding this technology.
Cell adhesion on biologically-compatible materials is considered essential for long-term implant biocompatibility. Our research involves the modification of a recently patented molecule that contains L-3,4-dihydroxyphenylalanine (DOPA) and other bonding peptides to increase osseointegration on metal surfaces, particularly titanium. Lab results have been encouraging: when coated with this molecule, titanium surfaces showed increased cell counts, survival rates, and overall health compared to non-treated surfaces. Furthermore, the peptide showed outstanding stability in aqueous solutions. This is backed up by published research attached to this offer. Attached is additional information regarding our technology offer.
The technology offers the following advantages:
- Effective, modified molecule for the improvement of the osseointegration of implants, reducing the risk of implant migration, inflammation, or loosening.
- Excellent binding of the proteins to metal surfaces, in particular titanium
- Very good peptide stability in aqueous solution
- Coating may be enhanced with other substances
Applications
Development of more bio-compatible surgical implants or medical devices where osseointegration is a key aspect of implantation success. Examples include dental, orthopedic, and spine implants, which are typically made using bio-compatible materials such as titanium.
Current development status
Experimental technologies
Desired business relationship
Technology selling
Patent licensing
Technology development
Other