CSIC and the University of Athens have found that secoiridoids, such as oleacein and oleocanthal, are
useful to prevent or treat illnesses that results in immune-mediated gastrointestinal alterations.
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An offer for Patent Licensing
New wide anti-inflammatory treatment
Oleacein (OLE) treatment reduces oxidative stress in colon tissue Immune-mediated inflammatory disease (IMID) is a term used to define a group of clinically heterogeneous, unrelated disorders that are recognized to share common inflammatory pathogenic mechanisms, The incidence of these autoimmune and inflammatory diseases has increased worldwide, and is being considered a health concern asociated to modern lifestyle, dietary habits, antibiotic intake and hygiene environment.. Genetic factors also play a crucial role.
IMID is associated with comorbidities that extend beyond the primary target organ. Thus, many conditions in which symptoms are not localized to the gastrointestinal system often involve an underlying gastrointestinal dysfunction.
The researchers have found a new treatment for these intestinal alterations using oleacein and oleocanthal as agents that markedly reduced the major hallmarks of gastrointestinal dysfunction. This opens a new approach to the treatment of inflammatory bowel diseases, as well as multiple sclerosis, chronic obstructive pulmonary disease, Crohn’s disease, ankylosing spondylitis, systemic lupus erythematosus (SLE), and psoriasis/psoriatic arthritis and myocarditis.
Main innovations and advantages
· These products are natural substances that can be isolated from olives,and could be used as a supplement to the diet or in nutraceuticalpreparations · May be used in combined therapies · Preventive capabilties
The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.
It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.
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