An advanced and cost effective bioresorbable, biocompatible polymer composite for bone soft tissue fixation has been developed, and their use in preparing different orthopedic devices that serves the purpose of fixation of soft tissue injuries and low-load bearing bone fractures. The use of the given bioresorbable polymer composite in orthopedic devices is an attempt to replace the traditional metallic implants and making it accessible to masses at affordable prices, and therefore overcome the limitations of currently available bioresorbable orthopedic devices in the market.
The technology produces a novel bioresorbable, biocompatible polymer composite for bone soft tissue fixation. The polymer composite biomaterial is composed of bioresorbable polymer such as poly-ε-caprolactone (PCL), natural fiber silk fibroin and an osteoconductive component like Magnesium oxide (MgO) in nanoparticle form and it can be used to prepare different orthopedic devices. The silk fiber of 20% and MgO nanoparticles in concentration of 10% were mixed together with PCL as base polymer in twin-screw extruder to produce composite orthopedic biomaterial. The newly developed bone screw is having a design with screw head shape, thread-tip design, thread profile and volume. It is found that millions of screws are being used for bone or soft-tissue fixations per year and the need of such fixations devices in world orthopedic market is ever-growing. The cost effective bioresorbable composite device thus made is also having wider clinical applications with its higher bioactivity (biomineralization), biocompatibility, infection resistivity and proper bone remodeling properties.
The main objective of using the bioresorbable polymer composites in orthopedic devices is to cater to the need of fixing soft tissue fixation. The aforementioned polymer composite slowly dissolve in the human body, thereby eliminating the need for a second operation to remove the implants after the healing procedure.
A novel and cost effective bioresorbable, biocompatible polymer composite for bone soft tissue fixation has been developed, which is used to prepare different orthopedic devices which serves the purpose of fixation of soft tissue injuries and low-load bearing bone fractures.
The composite biomaterial is a blend of bioresorbable polymer such as poly-ε-caprolactone (PCL) (40 to 90 wt%), natural fiber silk fibroin (5 to 30 wt%) and an osteoconductive component like magnesium oxide (MgO) in nanoparticle form (5 to 30 wt%). The improved mechanical properties and strength of the orthopedic devices manufactured using the polymer composite is attributed to the presence of natural fiber silk fibroin. The addition of MgO nanoparticles to enhances osteoblast functions and retains the superior mechanical properties of polymer composite for bone applications, with an additional benefit of antibacterial potential of MgO nanoparticles.
The device manufactured is very low cost due to its indigenous development and promises to offer superior qualities due to its advanced composition.
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