Scientists from the University of Granada in collaboration with the Spanish National Reseach Cuncil (CSIC) have developed a procedure for fabricating a composition made with a hydrogel that contains crystalized proteins with pharmacological activity with a medium size of 12 microns, that can be even smaller up to 5 microns.
The group has focused their work with insulin, though other proteins with therapeutic interest can be used. In any case, the crystalized proteins with pharmacological activity grow in situ inside de hydrogel.
DESCRIPTION
The group has focused their research work with insulin, being able to generate injectable compounds that contain insulin mycrocrystals obtained in media with biocompatible hydrogels and biodegradable, elaborated from agarose and dialanine. The technology can be used with other proteins with therapeutic interest, such as for example recombinant albumin and alkaline phosphatase.
A number of in vivo studies have been carried out Wistar male rats, since they show a low specifity for insulin of other species, using then two types of insulin, one made with agarose gel and the other with dialanine gel.
The rats which were administered the agarose preparation showed an identical absorption profile as the reference sample of insulin, which indicates a similar absorption kinetic.
On the other hand, the rats which were administered the dialanine preparation showed a lower absorption profile, since the insulin levels in blood remained constant.
This innovation has been made with the support of “Obra social la Caixa, through the Caixaimpulse program, a program of Obra Social La Caixa, co-organized with Caixa Capital Risk”. More information available in the next link: https://www.caixaimpulse.com/en/projects/-/caixaimpulse/project/29688
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