Our objective is to generate a recombinant minibody composed of anti-CD20 single chain antibody linked to mortalin mimetic peptides. It is intended for treatment of hundreds of thousands of patients diagnosed with early stage indolent B-chronic lymphocytic leukemia (CLL). CLL is the most common leukemia in the Western world accounting for about a third of all leukemias in the USA causing about 4,500 deaths a year. In most patients the disease will be indolent, yet a cohort of patients will have a rapid disease progression and poor prognosis. Despite a wide range of treatment options, a substantial number of patients succumb to their disease. Most of the current treatment modalities for CLL are non-specific and impose high risks of adverse outcomes. The therapeutic efficacy of anti-cancer antibodies as single agents has been rather limited and currently the antibodies are being applied in combination with conventional chemotherapy and radiotherapy. The novel recombinant minibody is expected to potentiate the anti-cancer effect of anti-CD20 antibodies and of other conventional therapies. Due to its selectivity to CD20-positive cells, the off target effects of this novel biotherapy are expected to be minimal. It is conceivable to assume that treatment at the early phase with an effective yet non-toxic therapy will enhance the prospect to achieve complete cure from CLL.
Project ID : 10-2014-822
Project manager
Adi Elkeles
BD Manager
Project researchers
Zvi Fishelson
T.A.U Tel Aviv University, Medicine-Sackler Faculty
Cell and Developmental Biology
Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at the university to industry's attention. The company provides the legal and commercial frameworks for inventions made by TAU faculty, students and researchers, protecting discoveries with patents and working jointly with industry to bring scientific innovations to the market.
Create your free account to connect with RAMOT at Tel Aviv University Ltd. and thousands of other innovative organizations and professionals worldwide
Send a request for information
to RAMOT at Tel Aviv University Ltd.
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
