A novel approach for the treatment of AMI has been developed using IOPs. IOPs, when injected into the infarcted myocardium, lead to improved heart function after MI. IOPs activate anti-inflammatory macrophages and thus promote tissue healing and repair and prevent myocardial remodeling and dysfunction.
Potential Applications
IOPs can be used to treat AMI and other inflammatory conditions associated with pro-inflammatory activated macrophages and to promote tissue healing and repair.
Advantages
? IOPs are nontoxic
? IOPs are FDA approved for use in humans for MRI imaging
Stage
In vivo studies in mouse and rat models of MI and heart failure
Project ID : 10-2011-247
The Technology
A novel approach for the treatment of AMI has been developed using targeted IONPs. Targeted IONPs, when injected into the infarcted myocardium or i.p., lead to improved heart function after MI. Targeted IONPs activate anti-inflammatory macrophages and thus promote tissue healing and repair and prevent myocardial remodeling and dysfunction.
Background
Macrophages control the initiation, maintenance and resolution of inflammation. One of the earliest phases after MI involves acute inflammation leading to fibrosis and scar formation. Macrophages are essential for infarct healing and repair. Some macrophages exhibit a pro-inflammatory cytokine profile (M1 polarization), whereas others show an anti-inflammatory profile and tissue repair activity (M2 polarization). IONPs are used to treat anemia and to label and track inflammatory and stem cells by MRI and are considered the most sensitive existing markers for cell labeling using MRI. They are nontoxic and biodegradable and do not affect proliferation and multi-lineage differentiation capacity in vitro.
The Need and Potential Application
Targeted IONPs can be used to treat AMI and other inflammatory conditions associated with pro-inflammatory activated macrophages and to promote tissue healing and repair.
Advantages
Nontoxic
FDA approved for use in MRI imaging in humans
Off –the-shelf
Drug repositioning pathway
Stage of Development
In vivo studies in mouse and rat models of MI and heart failure have demonstrated that targeted IONPs switch infarct macrophages from pro-inflammatory (M1) to reparative (M2) phenotype and improve remodeling and function after MI in mouse. In vivo wound healing studies demonstrated the efficacy of using targeted IONPs in improving wound healing.
Patents
PCT/IL2011/000300
Project manager
Elisha Natan
Director BD
Project researchers
Rimona Margalit
T.A.U Tel Aviv University, Life Sciences
The Department of Biochemistry and Molecular Biology
Jonathan Leor
T.A.U Tel Aviv University, Medicine-Sackler Faculty
Neufeld Cardiac Res Inst.-Sheba
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