Harvesting Solar Energy: Hydrogen production by a semi-artificial photo-system

Summary of the technology

Harvesting Solar Energy: Hydrogen production by a semi-artificial photo-system
Project ID : 6-2008-56

Details of the Technology Offer

The Technology

An artificial ferredoxin-hydrogenase fusion enzyme (Fd-HydA) has been developed for the production of hydrogen gas in algae. The Fd-HydA fusion enzyme interferes with the formation of the naturally occurring ferredoxin-sugar production pathway in photosystem I (PSI) complex and shuttles the donated electrons directly to the hydrogenase as shown in in vitro studies. Preliminary expression of Fd-HydA in algae supports hydrogen production.

Stage of Development

  • Fd-HydA fusion enzyme has been constructed and expressed in E. coli and evidence of electron transfer has been demonstrated in vitro
  • Fd-HydA fusion protein increases rate of hydrogen photoproduction by 400% in vitro
  • Fd-HydA fusion protein has specific activities of 3000 U (U = 1 µmol hydrogen mg−1 min−1) for hydrogen evolution from reduced methyl viologen (MV).
  • Fd-HydA fusion enzyme is expressed and active in alga (preliminary work).

These results suggest a new direction for improvement of biohydrogen production and a means to further resolve the mechanisms that control partitioning of photosynthetic electron transport.

Patent Status

WO2010/137019 (US, EP)

WO 2009/013745 (US)

Project manager

Elisha Natan
Director BD

Project researchers

Itai Benhar
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Iftach Yacoby
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Ehud Gazit
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Nathan Nelson
T.A.U Tel Aviv University, Life Sciences
The Department of Biochemistry and Molecular Biology

Related Keywords

  • Safety
  • Environment
  • Water Management
  • Oil and Gas Exploration and Production
  • Alternative Energy
  • Power generation
  • Energy Storage
  • Chemicals and Materials
  • Pollution and Recycling Related
  • Environmental and Cleantech
  • Environmental and Cleantech
  • renewable energy
  • cleantech

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