Bisphosphonate-conjugated beta lactamase inhibitors with potential to enhance antibiotic treatment efficacy of bone infections including osteomyelitis.
Researchers at the University of Alberta have developed bone-targeting beta-lactamase / beta lactamase inhibitor compositions to treat bone infections. In vitro studies show that, when administered with piperacillin, bisphosphonate conjugated tazobactam shows equivalent MIC against beta lactamase producing E. coli compared to tazobactam + pipercillin without bisphosphonate. This technology may increase antibiotic levels within the osteocyte-lacunar-canalicular network (OLCN) of bone, reducing systemic antibiotic accumulation. Lower systemic antibiotic concentration is projected to mitigate the risk of adverse effects, such as hypokalemia, nephrotoxicity, and jaundice, while aiding in the prevention of drug-resistant organisms.
Osteomyelitis (OM) is an inflammatory process of the bone caused by an infectious organism(s) that can quickly become limb- or life-threatening. OM has long been a clinical challenge and burden to healthcare, limited by the poor bone distribution of standard antimicrobial therapy. This technology may address the pharmacokinetic barrier by accumulating antimicrobials at high concentrations around the infection site, increasing their efficacy.
Transforming discoveries and innovations into reality is a complex and lengthy process. UAlberta’s Technology Transfer Services (TTS) team helps facilitate this journey. Part of the Vice-President (Research and Innovation) portfolio, TTS helps researchers, postdoctoral fellows, staff and students transform innovations and discoveries into reality—moving them out of the university to benefit society, the economy, the world.
Create your free account to connect with University of Alberta, Technology Transfer Services and thousands of other innovative organizations and professionals worldwide
Send a request for information
to University of Alberta, Technology Transfer Services
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
