Background
Approximately 300 million people will die prematurely as a result of antimicrobial drug resistance over the next 35 years resulting in the loss of 60 and 100 trillion USD worth of economic output by 2050 if the spread of antimicrobial drug resistance is not brought under control. Misdiagnosis of bacterial infection and overuse of antibiotics both contribute to antibiotic resistance. It is estimated that per cent of all antibiotic prescriptions world-wide are for β-lactam antibiotics (e.g. penicillins, cephalosporins, carbapenems), thus the emergence of wide-spread resistance to this class of antibiotics is of particular concern. Current beta-lactamase assay kits utilize Nitrocefin, which is expensive to synthesize, requires refrigerated storage, and has limited applicability to detecting only a sub-set of beta-lactamase producing bacterium. Thus it is imperative to develop diagnostic methods that more quickly, conveniently, and broadly identify the presence of beta-lactamase activity so that an appropriate antibiotic therapeutic strategy is selected.
Description of the invention
A novel chromogenic composition of matter (Aubergen2) has been synthesized that provides a deep purple colour change upon reaction with a broad spectrum of bacterial produced beta-lactamase. The colour change observed is substantially more distinct than Nitrocefin, the current commercial chromogenic beta-lactamase detection substrate.
Advantages
Potential applications
The University of Waterloo, renowned for its innovative spirit and co-op education model, excels in cutting-edge research across diverse fields, including advanced manufacturing, artificial intelligence, sustainability, and health technologies.
Create your free account to connect with University of Waterloo and thousands of other innovative organizations and professionals worldwide
Send a request for information
to University of Waterloo
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
