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- Potential treatment for diabetes, obesity, and related metabolic diseases.
- The protein FGFBP3 enhances FGF binding affinity, causing long-term reduction in hyperglycemia and gluconeogenesis in affected patients.
- Safer alternative to current diabetes treatments, as it does not cause life-threatening hypoglycemia or promote mitogenic effects, and normalizes blood sugar levels for over 24 hours after a single dose.
OVERVIEW
Georgetown researchers demonstrate that a single injection of the protein FGFBP3 alone is enough to restore the body’s ability to regulate insulin and blood sugar levels to a healthy range for more than 24 hours. Our researchers show that FGFBP3 enhances the binding affinity of Fibroblast Growth Factors 15/19 (FGFs15/19) to their preferential receptors, leading to a normalization of hyperglycemia, and reducing G6PC expression and gluconeogenesis.
BACKGROUND
Metabolic syndrome, if left unmanaged, can lead to stroke, type 2 diabetes, heart disease, non-alcoholic fatty liver disease, and even death. This syndrome is characterized by an unfavorable dysregulation of fat and glucose metabolism. Therefore, treatments with the ability to promote favorable metabolic signaling could be used to improve the health of patients with metabolic syndrome and manage associated pathologies.
Benefit
Use of FGFBP3 for the treatment of diabetes, obesity, and related metabolic diseases
Market Application
Publications
Our mission is to advance GU’s innovations through strategic alliances and new venture creation, to facilitate the translation of research breakthroughs into tangible solutions, and to cultivate a dynamic and inclusive environment for entrepreneurship. We advance this mission in support of the GU community and for the benefit of society.
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