- PARCI-MS revolutionizes elemental quantitation, achieving 100 times better sensitivity for fluorine quantitation than current methods, ensuring unparalleled precision in measurements.
- The innovation requires only one standard per element, streamlining workflows by eliminating the need for compound-specific calibrations and reducing experimentation time and costs.
- PARCI-MS facilitates the simultaneous measurement of multiple elements, enabling rapid quantitation and identification of compounds in pharmaceuticals, environmental samples, food products, and forensic materials.
OVERVIEW
Georgetown University's Plasma Assisted Reaction Chemical Ionization (PARCI)-MS innovation enhances elemental quantitation in mass spectrometry. Unlike conventional methods, PARCI-MS enables precise measurement of nonmetal elements (F, Cl, P, S) with exceptional sensitivity and versatility. It eliminates the need for compound-specific standards, accelerating workflows and expanding applications in pharmaceuticals, environmental analysis, and more.
BACKGROUND
Current elemental ionization methods face limitations in mass spectrometry, hindering efficient quantitation of vital nonmetal elements. Traditional ICP-MS, reliant on thermal energy, falls short for elements like F, Cl, P, and S. Georgetown researchers address this gap with PARCI-MS, a groundbreaking approach to overcoming thermal ionization challenges. This method ensures high sensitivity, minimal calibration requirements, and applicability across diverse sample matrices, showcasing its potential in pharmaceuticals, environmental assessments, food analysis, and forensic investigations.
Benefit
● Enhanced sensitivity, surpassing existing methods by 100-fold for fluorine quantitation.
● Eliminate compound-specific standards, reducing experimental time and costs.
● Simultaneously measure multiple elements, providing rapid and precise results for various compounds.
● Tolerant to complex sample matrices, requiring only one calibration standard per element, simplifying quantitation processes.
Market Application
● Pharmaceutical Analysis: Efficient quantitation of elemental components in drug compounds, accelerating drug development processes.
● Environmental Contaminant Assessment: Rapid identification and quantitation of elements in environmental samples, aiding pollution control and remediation efforts.
● Food Industry Quality Control: Ensures elemental analysis in food byproducts, enhancing quality control measures.
● Forensic Investigations: Facilitates elemental profiling in forensic samples, supporting criminal investigations and evidence analysis.
● Biological and Chemical Research: Versatile application in diverse research areas involving elemental analysis.
Publications
US Patent No. 9,966,243
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