Quantitative Chirality and Concentration Sensing of Chiral Analytes Using a Relay Assay

Summary of the technology

- The technology allows for the simultaneous determination of absolute configuration, enantiomeric composition, and concentration, surpassing conventional methods
- With capabilities for multiwell plate technology, the assay streamlines processes, enabling rapid screening of numerous samples
- From chiral amines to challenging mono-alcohols, our assay demonstrates versatility, offering a wide scope of compound analysis

Georgetown University

Details of the Technology Offer

OVERVIEW

Georgetown University researchers developed an analytical method that offers a comprehensive solution for determining both the absolute configuration and concentration of chiral analytes, surpassing traditional techniques. The assay enables simultaneous data acquisition, innovating the landscape of analytical chemistry. With this method, users can seamlessly probe the absolute configuration, enantiomeric composition, and concentration of chiral compounds in a single assay, leveraging chiroptical and non-chiroptical techniques. The technology ensures accurate and reliable results, expediting analytical processes.Its compatibility with multiwell plate technology, enables high-throughput screening without compromising accuracy.

BACKGROUND

In the field of analytical chemistry, the quest for efficient and comprehensive methods for chiral compound analysis persists. Traditional approaches, characterized by sequential procedures and limited throughput, have long impeded progress in this domain. This innovation addresses this challenge, introducing a relay assay that integrates chiroptical and non-chiroptical techniques. It enables researchers to acquire knowledge into the absolute configuration, enantiomeric composition, and concentration of chiral analytes with unprecedented efficiency and accuracy. This technology is compatible with a wide range of chiral compounds, including challenging mono-alcohols, this method demonstrates its applicability across diverse chemical contexts.

Benefit

  • Enhanced Efficiency: Offers rapid and accurate analysis of chiral molecules, reducing time and resources required for analytical processes.
  • Comprehensive Insights: Provides detailed information on both the configuration and concentration of chiral analytes, supporting informed decision-making in research and development.
  • Compatibility with Industry Needs: Meets the demands of industries such as pharmaceuticals for fast and reliable analytical methods for chiral compound analysis.

Market Application

  • Offers rapid and accurate analysis of chiral molecules, reducing time and resources required for analytical processes.
  • Provides detailed information on both the configuration and concentration of chiral analytes, supporting informed decision-making in research and development.
  • Meets the demands of industries such as pharmaceuticals for fast and reliable analytical methods for chiral compound analysis.
  • Optimize production processes by monitoring chiral compound concentrations and configurations.

Publications

US National Phase Patent Application Filed No. 17/923,446

Related Keywords

  • Pharmaceutical Products / Drugs
  • Pharmaceuticals/fine chemicals
  • chromatography
  • compound
  • polarimetry
  • chiral

About Georgetown University

Our mission is to advance GU’s innovations through strategic alliances and new venture creation, to facilitate the translation of research breakthroughs into tangible solutions, and to cultivate a dynamic and inclusive environment for entrepreneurship. We advance this mission in support of the GU community and for the benefit of society.

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