Combined Determination of the Concentration and Enantiomeric Composition of Chiral Compounds Using Single Chiroptical Assay

OVERVIEW

Georgetown University researchers developed an innovative analytical method representing a significant leap forward in chiral compound analysis. Employing a singular chiroptical assay format enables researchers to concurrently determine both the concentration and the absolute configuration or enantiomeric/and or diastereomeric composition of chiral compounds within samples. This streamlined approach expedites the analytical process and offers a more comprehensive understanding of compound properties, revolutionizing the study and application of chiral molecules across various scientific disciplines.

BACKGROUND

Chirality presents challenges in compound analysis. Traditional methods are often complex, time-consuming, and require costly equipment. As demand for chiral compounds rises, efficient analytical techniques become crucial. Emerging optical methods, like fluorescence or circular dichroism (CD), promise streamlined analysis. However, they often necessitate extensive derivatization or cannot simultaneously determine the concentration and chiral configuration. The method outlined introduces a unified approach, combining concentration determination with chiral configuration analysis using a single chiroptical assay format. Employing a chromophore probe enables rapid and accurate assessment of chiral compounds, offering unprecedented efficiency and versatility in chiral compound analysis

Benefit

• Enhanced Efficiency: Offers a rapid and comprehensive solution for chiral compound analysis, reducing analysis time and resource requirements.
• Improved Accuracy: Enables simultaneous concentration and chiral configuration determination, providing detailed insights into compound properties.
• Cost-Effective: Reduces labor and material costs associated with traditional analytical techniques like NMR spectroscopy and chiral chromatography, making it economically advantageous for research and development.

Market Application

• Facilitates efficient drug discovery processes by providing rapid and accurate analysis of chiral compounds.
• Supports research and development efforts in designing chiral materials with specific properties and applications.
• Enables detailed characterization of chiral compounds, aiding in developing novel chemical reactions and synthesis strategies.

Publications

• US National Phase Patent Application Filed No. 18/682,596