- Targets CD99+ cancers with specific small molecule inhibitors for improved treatment efficacy.
- Utilizes membrane impermeable CD99 inhibitors to enhance therapeutic specificity.
- Provides a dual application in treating both cancer and autoimmune disorders.
OVERVIEW
This invention presents novel small molecule inhibitors of CD99, offering a new therapeutic approach for treating bone and connective tissue cancers, particularly those expressing CD99 antigens. The CD99 inhibitors, including clofarabine, cladribine, and their 5' triphosphate analogs, are designed to target CD99+ cancers effectively. The treatment involves administering these inhibitors in effective amounts to patients, providing a potentially superior alternative to existing cancer therapies by focusing on the CD99 antigen, thus enhancing the specificity and efficacy of the treatment.
BACKGROUND
Cancer remains a leading cause of death globally, with over 1.6 million new cases diagnosed annually in the US alone. There is a significant demand for more effective and targeted cancer treatments. Additionally, autoimmune diseases affect over 50 million Americans, highlighting the need for novel therapeutic strategies. The development of CD99 inhibitors addresses these critical healthcare challenges by offering targeted treatment options for CD99+ cancers and autoimmune disorders.
Benefit
Market Application
Publications
US Issued patent No. 11,202,792
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