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This new analogues can be used to develop new drugs with antitumor action or with action on other diseases by acting on the VDR receptor with low or negligible toxic calcemic side effects. The innovative aspects are i) diminished or non-calcemic side effects and ii) slower proliferation rates of tumoral cells.
This invention relates to the synthesis and biological applications of new vitamin D analogues based on the C-to-Si exchange in the side chain, along with several groups at the Si atom, such as alkyl, hydrogen, or hydroxyl. It is focused on i) 1,25D derivatives, ii) procedures for obtaining them, iii) their intermediates, and iv) their pharmacological applications. The new analogues can be used to develop new drugs with antitumor action or with action on other diseases by acting on the VDR receptor (psoriasis, Alzheimer's, osteoporosis, diabetes, hypertension, low immunity, rickets) with low or negligible toxic calcemic side effects.
The new analogues have a similar cell differentiation in comparison with 1,25D with diminished or non-calcemic side effects. One of the analogues is responsible for significantly increasing the weight of the animals which may suggest an increase in bone density. It was observed a slower proliferation rate of tumoral cells and a great ability to activate target genes of 1,25D for all analogues and 1,25D in comparison with the control.
Applications
Potential comercial uses/applications: Drugs - Prophylactic and/or therapeutic agent for vitamin D receptor-related diseases; Supplements - Prophylactic agent for vitamin D receptor-related diseases
Desired business relationship
Technology selling
Patent licensing
Joint ventures
Technology development
New technology applications
Adaptation of technology to other markets
Current development status
Experimental technologies
U.Porto Innovation focuses its activities on research at the University, entrepreneurship within the academic community and U.Porto’s growing connections with industry.
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