The subject of the offer is a unique nucleotide sequence capable of specifically bindin to the PD-L1 protein, which could be used to obtain selective markers for use in cancer imaging across a broad spectrum of diagnostic techniques.
Cancer is a well-known health problem, ranking high in terms of mortality worldwide. One of the pillars of modern cancer diagnosis and treatment is biomedical imaging, which is used at all stages of the diagnostic process - from screening and assessing the stage of the disease to planning therapy and verifying its effects. Early and effective diagnosis is an important factor in reducing mortality, treatment costs and hospital stays. The use of highly specific molecular probes in imaging techniques provides the opportunity to visualize tumor development at a very early stage. Many studies to date have shown that aptamers are among the best imaging tools due to their high stability, target specificity and affinity. Moreover, aptamer probes offer the added benefits of reduced immunogenicity, structural stability and smaller particle size.
Researchers from the Jagiellonian University have developed a single-stranded aptamer-based molecular probe that specifically recognizes a ligand protein for the programmed death receptor (PD-L1). PD-L1 is a protein present on the surface of many cells in the human body. Its presence on normal cells prevents them from being destroyed by immune cells. Some, but not all, cancer cells have significant amounts of PD-L1, enabling them to evade the body's natural defense system. Therefore, molecular probes that target PD-L1 binding will be able to detect and localize cancer cells at a very early stage of the disease.
In vivo experimental studies on two different mouse models have confirmed the potential of the proposed probe in tumor imaging. Its further development will allow to develop a tool for universal imaging of different types of tumors depending on their ability to overexpress PD-L1 protein. The proposed solution may find applications in: optical imaging (fluorescence and bioluminescence), magnetic resonance imaging, positron emission tomography, single photon emission tomography, computed tomography and ultrasound.
The CITTRU Technology Transfer Center is looking for entities interested in the commercial use of the invention.
Intellectual property status
Patent already applied for
Patent application number :
Where : Poland: P.441076
Patent already applied for
Patent application number :
Where : PCT: PCT/PL2023/050030
Current development status
Laboratory prototypes
Desired business relationship
Technology selling
Patent licensing
Joint ventures
Technology development
Jagiellonian University, founded 1364, is the oldest university in Poland and one of the oldest worldwide. The research and teaching activities are conducted at 15 faculties, including the Medical College (Collegium Medicum). Over 3,700 researchers work at the university and the total number of students is about 50,000.
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