A vaccinia virus vaccine (ΔF4LΔJ2R) engineered for safety and designed to replicate precisely rapidly dividing cells
Bladder cancer candidate UAB-211 infects BCG-resistant cells and outperforms BCG in animal models.
Animal data in a highly aggressive bladder cancer model shows a 50% long-term complete response
ΔF4LΔJ2R vaccinia + radiation has shown efficacy in an animal model of glioblastoma
University of Alberta researchers have developed a strain of vaccinia virus with a mutation in the ribonucleotide
reductase (RR) small subunit (ΔF4LΔJ2R). This modification makes the virus preferentially replicate in host
cancer cells, which are known to over-express the small subunit of RR.
Pre-clinical data
● The safety and efficacy of UAB-211 have been tested in orthotopic and immune-competent tumor models.
It infects BCG-resistant cells and outperforms BCG in a rat bladder cancer model.
● cGMP master virus seed production completed.
● Complete QC analysis conducted by a qualified third-party
● High-dose testing of UAB-211 in a rat model
Current development status
Working prototypes
Desired business relationship
Patent licensing
Joint ventures
Technology development
Transforming discoveries and innovations into reality is a complex and lengthy process. UAlberta’s Technology Transfer Services (TTS) team helps facilitate this journey. Part of the Vice-President (Research and Innovation) portfolio, TTS helps researchers, postdoctoral fellows, staff and students transform innovations and discoveries into reality—moving them out of the university to benefit society, the economy, the world.
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