The Challenge
Nowadays, there is a growing need for lab-on-chip devices especially in clinical analysis and diagnostics. First step in most blood assays is plasma extraction from whole blood.
Compared to traditional centrifugation processes ”lab-on-a-chip” devices minimize the manipulation errors, reduce the time from blood collection to the test and provide faster and yet less expensive and comprehensive results since the amount of sample and reagents are drastically reduced. Although many researchers have developed plasma separation from whole blood utilizing different techniques, the volume of extracted plasma and the separation time are the two main barriers to implement the current commercial test on microfluidic platforms.
The Technology
This patent presents a novel high throughput blood plasma separation microfluidic chip which has been designed and fabricated to be used as first step in a point-of-care Device to maximize the amount of plasma extracted from a single blood droplet. Hydrodynamic behavior of red blood cells in a constriction channel is the base for plasma extraction using a symmetric cross flow filtration MIMP (Microchannel Integrated Micro-Pillars) channel together with electrokinetic techniques are used to maximize the amount of extracted plasma and minimize the time required for a complete separation.
Innovative advantages .
Current stage of development
Prototypes have been developed and tested. An industrial manufacturing process is defined.
Applications and Target Market
Clinical Laboratories and In Vitro Diagnostic Industry
Innovative advantages
The Universitat Politècnica de Catalunya - BarcelonaTech is a public institution dedicated to higher education and research in the fields of engineering, architecture and science, which contributes its knowledge and expertise in order to increase scientific output, transfer its results to society and provide a network of scientific and technical state-of-the-art facilities and technology valorization services that place us at the leading edge of innovation and economic development.
The UPC has established itself as a driver of innovation and is the technology partner of choice for companies and organizations with which it develops projects and builds partnerships. A role borne out by the numerous agreements and research projects that have been set in motion by groups, organizations and laboratories; the creation of new technology-based companies; the generation and exploitation of patents, and the scientific and technical services UPC makes available to its environment in order to generate progress and employment.
The Technology Transfer Office (SGI) is responsible of Designing, coordinating and implementing research valorisation strategies, carrying out the protection policy of the research results, marketing these results through license contracts and designing and setting up the University's enterprise creation model in order to transfer the results of the research to the market, protect and commercialize these results, promote the culture of entrepreneurship and innovation, and create technology-based companies within the UPC environment.
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