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Leading BiologyLeading BiologyLeading Biology posted this:
Protein Expression in E coliLeading Biology has extensive experience and is very professional in E. coli protein expression and purification. We can solve various difficult problems during the protein expression and purification process.
Business Development Manager at Leading Biology
Unismart - University of Padua FoundationUnismart - University of Padua FoundationUnismart - University of Padua Foundation posted this:
Protein extraction method for diagnosticsThis patent defines a new method for the extraction and identification of proteins starting from a small quantity of biological material. The first diagnostic application that is currently at an advanced stage of development and validation is in the diagnosis of amyloidosis.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.
Vilnius UniversityVilnius UniversityVilnius University posted this:
ProteinGAN – deep learning framework for rapid generation of highly-functional synthetic enzyme librariesThe immense size of protein sequence space and poor understanding of sequence-function relationships renders current protein library design methods highly inefficient. Deep learning based technology developed by Biomatter Designs – ProteinGAN – provides a way to generate highly diverse and functional synthetic enzyme libraries. Due to high amounts of mutations in each synthetic enzyme sequence (up to 50% currently shown) and their retained catalytic activity, the designed libraries can be subjected to exceptionally potent screening for improved activity, thermostability and other characteristics.
Creative Proteomics posted this:
Proteomic ServiceCreative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals.
UACOOPERA University of AveirouacooperaUACOOPERA University of Aveiro posted this:
PSA purification and concentration from urine samples for non-invasive early stage diagnosis of prostate cancerNew method for the pretreatment of human urine sam-ples, comprising the simultaneous extraction, concentration and purification of the prostate-specific antigen (PSA), a prostate cancer biomarker. In this technology, aqueous biphasic systems composed of ionic liquids and salts are used. These systems allow the selective extraction of PSA and to obtain high con-centration/enrichment factors, enabling the quantification of PSA using less sophisticated, cheaper and more affordable equipment.
Technology Transfer Office at uacoopera
Fundació UdG Medicina posted this:
PSICODEM is a very simple software. It allows you to choose the most appropriate psychosocial intervention for people suffering from dementia, depending on their level of cognitive impairment and other signs and symptoms such as aphasia or anxietyIt is a very simple software. It does not needt to be installed, just needs internet access, together with a user name and password. It is very easy to use and very useful when professionals need to take quick decisions based on best existing evidence. They have to consider level of patient's dementia according to MMSE test and study their signs and symptoms in order to obtain the best psychosocial intervention that is recommended.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Purine derivatives for the treatment of neurodegenerative diseasesCSIC has synthesized several substituted purine derivatives that are capable of inhibiting the activity of the CDC7 kinase. This inhibitory activity makes them useful for the treatment of neurological diseases. The compounds developed are, therefore, a new therapeutic alternative for Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia. Industrial partners from pharmaceutical industry are being sought to develop and commercialized the compounds through a patent licence agreement. An offer for Patent Licensing
University of Vigo posted this:
Pyridazin-3(2H)-one Derivatives as Selective Inhibitors of Monoamine Oxidase-B Isoform (MAO-B)This invention is concerned essentially with pyridazinone derivatives substituted at C4, C5 or C6 with dithiocarbamate fragments that are selective MAO-B inhibitors, and their use for the preparation of medicaments for treating disorders resulting from MAO-B hyperactivity, including neurodegenerative diseases, such as Parkinson´s and Alzheimer’s diseases and other dementias. The pyridazine ring is a privileged fragment found in compounds with very different pharmacological properties, such as antihypertensive, antiplatelet, anti-inflammatory, antinociceptive, antidepressant, hypoglycemic, antiinfective or anticancer agents, many of them being pyridazin-3(2H)-one derivatives. The pyridazine ring is also included in polycyclic compounds acting as MAO-B inhibitors. However, simple pyridazin-3(2H)one derivatives have not been described so far as selective MAO-B inhibitors. The present invention provides novel pyridazin-3(2H)-one derivatives substituted at C4, C5 or C6 with several dithiocarbamate moieties that selectively inhibit the MAO-B activity and whose structure is unrelated to those currently available. Innovative aspects and advantages The novel pyridazin-3(2H)-one derivatives can be easily synthesized through a multicomponent reaction, in which the appropriate 6(5)(4)-bromoalkyl analogue, an amine and carbon disulfide react in the presence of anhydrous potassium phosphate at room temperature. The compounds of the present invention were inactive against MAO-A. However, these simple pyridazinone derivatives are inhibitors MAO-B with IC50 values in the micromolar range. Commercial applications and potential users The compounds of the present invention or their salts could be used by the pharmaceutical industry for the preparation of medicaments to treat disorders resulting from MAO-B hyperactivity, including neurodegenerative diseases, such as Parkinson´s and Alzheimer’s diseases and other dementias.
Peter Mogyorosi posted this:
Pyrolysis of carbonized Polyvinyl Chloride (PVC) waste to produce hydrochloric acidThis unique technology converts carbonized PVC waste into hydrochloric acid and uses mixed carbonized plastic waste as an energy source. This machine is suitable for processing PVC waste which comes from electric cables and construction waste or other sources, like the byproduct of Refuse-derived fuel (RDF) production.
CEO at Laser Consult Ltd.
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Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Quantitative Auxiliary-free Chirality Sensing with a Metal Probe- Simplified sensing assay with reduced cost and waste - Achievable with ligand-free, earth-abundant cobalt salts - Determination of the absolute configuration and the enantiomeric composition of the chiral analyte
- Georgetown UniversityGeorgetown University
Georgetown University posted this:
Quantitative Chirality and Concentration Sensing of Chiral Analytes Using a Relay Assay- The technology allows for the simultaneous determination of absolute configuration, enantiomeric composition, and concentration, surpassing conventional methods - With capabilities for multiwell plate technology, the assay streamlines processes, enabling rapid screening of numerous samples - From chiral amines to challenging mono-alcohols, our assay demonstrates versatility, offering a wide scope of compound analysis
Niklas GuentherTransMIT GmbHNiklas Guenther posted this:
Quantum Imaging with Undetected PhotonsYou are working in the area of methods of imaging, spectroscopy or photometry? Then the new method of quantum imaging with undetected photons („QUIP“), developed at the university of vienna, is exciting for you. It allows to take images from objects without the need of detecting the light, being scattered from the object. This is achieved by first splitting up a primary beam of photons into two separate beams of entangled photons having different wavelengths. The two split-up beams are now themselves splitted up into two quantum-entangled split-up beams of different wave-length, whereat each one of these split-up beams of second generation has a wavelength of one of the split-up beams of the first splitting up. The split-up beams of first and second generation having the same wavelength are now merged and superposed so that their photons are now no longer distinguishable from each other. Due to the entanglement of the „combination-beams“ being acquired this way and having different wavelengths from each other, the behaviour of the photons of one of the beams can be determined by measuring the photons of the other beam – while both combination-beams, being entangled with each other and having different wavelengths. The object which is to be investigated will be illuminated with one of the combination-beams and the other combination-beam will be „analysed“. By doing so an object is being illuminated with one wavelength and the detection of the „result“ of the illumination will take place at another wavelength. Hence, the method is based upon the emission of photon pairs from two coherent SPDC processes and spatial correlation within the photon pairs. The image is developing as interference pattern in one of the two beams, whereat the object is illuminated by the other beam. It is not necessary to detect the „object-beam“, because its behaviour can be derived from the „detection-beam“ at a different wavelength, due to their entanglement with each other. On behalf of UniVie we (TransMIT Society for Technology Transfer) are looking for cooperation partners in areas of optics, measurement technology and medical imaging for further development or licensees in Germany, Europe, US, and Asia. I look forward to your message. Thank`s.
Senior Innovation & Alliances Manager at TransMIT GmbH
University of Vigo posted this:
Quantum Random Number Generator QRNGThe invention is a Quantum random number generator (QRNG) device integrated in a photonic integrated circuit. This QRNG is a physical random device based on quantum sampling systems with macroscopically observable parameters that randomly vary dynamically, such as the phase or intensity of a laser or an optical amplifier, and are the future of cybersecurity. More specifically, it is a QRNG device integrated into a photonic integrated circuit or PIC (chip), manufactured using lnP technology. The generation of quantum numbers is based on the combination of phase noise produced in a laser cavity and interferometry.
Yeda posted this:
Quantum Simulation with Trapped Ions in a Gradient FieldProgress in a broad range of scientific and technological fields is hampered by the difficulty of understanding and predicting the behavior of highly complex systems. Simulating the behavior of these systems is difficult with classical computers but can be performed efficiently using quantum simulators. Currently, the scope of models which such simulators can accommodate with current techniques is restricted because of limitations in managing and configuring the ion chain. We have developed a novel technique for quantum simulation which significantly increase the range of models that can be implemented on a quantum simulator.
Antoni Mulero Punsí posted this:
Quick RESCUE. New foldable, self-inflating, light and highly portable device for water rescue and lifesavingAncillary device for water rescue and lifesaving. This small, light device is worn as a waist bag and self-inflates by means of a CO2 cartridge just before making contact with the bather in distress. The device fits snugly around the lifesaver’s waist, generates no resistance for swimming and leaves their hands free in order to carry out preventive lifesaving tasks. Its strong buoyancy once inflated makes it suitable for rescuing heavy or multiple victims.
HEALTH TECHNICIAN at DIPSALUT
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University Hospital Hradec KrálovéUniversity Hospital Hradec KrálovéUniversity Hospital Hradec Králové posted this:
R-ELLA Rehabilitation Pad - Unique rehabilitation device that helps patients exercise on the bedRehabilitation pad is an unique device that is intended for use on the patients’ bed during their hospital stay for active exercise of the lower limbs, abdominal and back muscles in order to maintain/improve physical condition and prevent complications from long-term hospitalization. It enables independent exercise without constant nursing staff assistance and the need for professional settings. The pad is also intended for home use. It has not been certified as a medical device yet. Intended use The rehabilitation pad is mainly intended for: • adults and adolescents from 12 years of age, with a minimum body height of 120cm, who are confined to bed for a longer period of time, and their health condition allows exercising • seniors, who have been confined to bed for a long period of time and need to strengthen the lower half of the body and rehabilitate walking • patients after acute illness that are being rehabilitated in home care Rehabilitation pad enables: • to exercise the lower limbs as soon as possible after recovering from critical condition • development of muscle strength of lower limbs, abdominal and back muscles • independent exercising and improving fitness that leads to earlier recovery Features / Benefits RELLA - unique rehabilitation pad enables patients that are confined to bed for a longer period simple exercising and rehabilitation leading to faster recovery, thus shortening the time of being confined to the bed and restoring physical condition leading to a faster return to the original quality of life. Main advantages • minimal supervision of other person needed • simple exercise of the lower limbs, abdomen and back • possibility to exercise the limbs alternately or both at the same time • sliding plates can be locked to ensure safe manipulation with the pad • the possibility of exercising with bandaged limbs • the pad can be used on any type of bed • easy manipulation (light weight) Dimensions The rehabilitation pad consists of a light aluminum structure measuring 820 x 630 x 50 mm, on which two plates measuring 250 x 258 mm are placed. The fastening belt is made of polyester. Use The pad is placed directly on the bed. To secure it against movement, it is attached to the bed by tightening the fixation belt. Patient lies on the bed in a supine position and the heels are placed on the sliding parts of the rehabilitation pad while the lower limbs are stretched. Movable plates enable exercise of the lower limbs by horizontal movement. During the flexion of the limbs at the hip and knee joint, it moves the feet towards the buttocks. During straightening in the hip and knee joint, it pushes the feet away from the buttocks. During these movements, the muscles of the lower limbs are strengthened (especially the thigh and calf muscles). At the same time, the abdominal muscles and the stabilizing muscles of the back are exercised. The plates move independently of each other, it is also possible to lock them and connect them together and thus perform exercises with both legs at the same time. The boards have a synthetic rubber top that ensures a non-slip surface. The exercise methodology is not structured in any way, and the procedure and frequency (exercise length) generally depends on the specific condition of the patient. All information & media is available at the ELLA-CS, s.r.o https://ellacs.cz/rella-rehabilitacni-podlozka
Jorian Bos posted this:
R3 ECHORING - High-performance wireless technology for mission-critical industrial applicationsUNWIRE AUTOMATION, BE BOLD. Turn your wired industrial applications into a wireless connected system to make them saver, faster, more flexible, efficient, durable, up and down scalable.
Other at EIT Digital
Daniel Sánchez PuertoInstituto de investigación Sanitaria Gregorio Marañon (IiSGM)Daniel Sánchez PuertoTechnology Innovation Manager at Instituto de investigación Sanitaria Gregorio Marañon (IiSGM)
View ProfileDaniel Sánchez Puerto posted this:
Radioactive compounds for non-invasive detection of Grampositive infectious diseasesIiSGM has developed a novel and selective proteinbased radiotracer [99mTc]-DTPA-Collagen for the selective detection of Gram-positive bacteria in nuclear medicine (SPECT, PET, etc). This radiotracer consist of the radioactive labelling of collagen type I.
Technology Innovation Manager at Instituto de investigación Sanitaria Gregorio Marañon (IiSGM)
Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget posted this:
Rapid Computational Screening of Natural Products for COVID-19 Anti-Viral AgentsSome edible compounds are potent antiviral agents and were tested successfully against SARS and MERS viruses. They hence provide an large source for rapid development and production of cure against COVID-19. These compounds are commercially available, and are generally recognized as safe (GRAS), with a vast chemical diversity. Despite the high-level genetic similarity to other coronaviruses, such as SARS-CoV and MERS-CoV, recent works demonstrate major structural differences in SARS-CoV2 (the causal agent of COVID-19 disease) proteins. The need for specific anti-SARS-COV2 treatments is acute. Rapid screening of the food derived compounds, using chemoinformatic modeling tools that are common in our lab, allow the identification of a small number of potent antiviral candidate inhibitors of recent published SARS-CoV2 target proteins. Project ID : 47-2020-10884
- Unismart - University of Padua FoundationUnismart - University of Padua Foundation
Northeastern University's Center for Research InnovationNortheastern University's Center for Research InnovationNortheastern University's Center for Research InnovationSmall and Medium Enterprise
Northeastern University's Center for Research Innovation posted this:
Rapid Gas-Phase Isotopic Labeling for Enhanced Detection of Protein ConformationsSeveral prior-art techniques such as ion mobility spectrometry and gas-phase HDX measurements have been used for assessing the conformational properties of gaseous protein ions. Most of these approaches comprise the use of ion traps or ICR cells where a gas is introduced and the ions are incubated with the gas. However, such approaches are associated with potential limitations such as extended gas-phase labeling time, complex exchange kinetics, and comparatively low gas pressure. This novel approach enables a rapid gas-phase isotopic labeling of protein ions for enhanced detection of protein conformations.
Taras MaiulaOtava Research InstituteTaras Maiula posted this:
RAR-related Orphan Receptor-γ Targeted LibraryThe Retinoic Acid Receptor-related Orphan Receptor-γ (RORγ, RORc, NR1F3, RORG, RZR-GAMMA, RZRG, TOR or IMD42) plays an important role in metabolism, inimmunity and circadian rhythm. Abnormal functioning of RORγ is associated with inflammatory, immune and skin diseases including psoriasis. Antagonists and inverse agonists of this receptor may have therapeutic potential in the treatment of such diseases. https://bit.ly/461Jypm
Head of the QC department at Otava Research Institute
Kyoto University posted this:
Rare metal recovery and recycling using DualPore™ TechnologyRare metals such as palladium are used as catalysts for manufacturing automobiles, semiconductors, and printed circuit boards. These trace metals then remain in solutions and waste liquids and are difficult torecover. The present invention is a new material, DualPore™ Silica, which can efficiently adsorb, separate, and recover trace metals and substances.
- Unismart - University of Padua FoundationUnismart - University of Padua Foundation
Unismart - University of Padua Foundation posted this:
Raw material recovery from solar panelsThe method and plant described in this patent are an effective means of separating the materials present in the panels, such as glass, copper, silver, aluminium and silicon. The panels go through a sequence of treatments that use easy to find and convenient reagents.
Radoslaw Rudz posted this:
Reactor for spectroscopic studiesNovel HT-IRS 01 reactor, with unique characteristics, is dedicated to working in a transmission mode of optical spectroscopy (for example IR spectroscopy). It may be easily combined with mass spectroscopy or gas chromatography.
Other at Jagiellonian University
IMDEA Energy posted this:
Real time emulation of electrical power networks, development and testing of control algorithms in energy systemsIMDEA Energy has created a test environment specifically designed for research, development and testing of control algorithms in energy systems. This Power-Hardware-In-the-Loop environment called “Smart Energy Integration Lab” is designed for accelerating the process of control design development necessary for integrating energy resources to electricity networks. This platform allows analysis, development and testing of realistic scenarios for AC and DC network integration and operation of distribution power networks, islanded networks and microgrids.
