Technology Offers Site map description
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Taras MaiulaOtava Research InstituteTaras Maiula posted this:
DOT1L Targeted Library (585 compounds)DOT1L is an attractive target for specific malignancies, such as leukemia. Inhibitors of DOT1L could potentially be used for anticancer therapy.
Head of the QC department at Otava Research Institute
Korea Institute of Energy ResearchKorea Institute of Energy ResearchKorea Institute of Energy Research posted this:
Double flow channel open-type solar heat absorberResearchers at the Korea Institute of Energy Research (KIER) have developed an innovative double flow channel open-type solar heat absorber. This technology particularly relates to a solar heat absorber which is formed into rectangular or circular-shaped cross sections to increase a contact area with collected sunlight, and which includes a main body formed using a three-layered tube to form a dual passage so that heat loss is prevented.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Double mesh prosthesis that corrects defects in the abdominal wall and prevents adhesion formation at the peritoneal interfaceA research group from the Surgery Department of Alcala University has designed an implantable prosthesis made of two meshes joined together, for abdominal surgery uses. This prosthesis prevents the erosion of the viscera by promoting mesothelial deposition. Both meshes induce fibroblast proliferation and collagen deposition achieving the definitive repair of the defect at the expense of connective tissue. This research group is looking for manufacturing and license agreements.- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Double port injector to corneal transplant DMEKThe Reseacrh group in Cell biology of solid tumors and tisular regeneration from Alcala University and the Research group in Cellular Engineering from University from Hospital La Paz, have developed a new injector designed to reduce endotellial damage during the corneal endothelial graft implantation in eye´s anterior chamber. The group is looking for cooperation or commercial agreement with companies manufacturers of sanitary products and medical devices, ophthalmological clinics and hospitals.
Brunel University LondonBrunel University LondonBrunel University London posted this:
Drag Reduction in Vehicles to increase fuel efficiency and reduce CO2For heavy goods vehicles (HGV) 10% drag reduction is achieved by combining a single embedded trough at the rear end of the vehicle roof and troughs at the rear end of each side of the vehicle. This will result in significant fuel efficiencies during operation. Brunel University London is seeking companies who are interested in partnering to scale up this patented design. This could be HGV trailer manufacturers or in related areas of manufacturing of cars, particularly high performance/speed vehicles, coaches, train carriages and boats.
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
DriveSafe: App that monitors and scores your driving, generating alerts when it is not safe.The RobeSafe group of the Department of Electronics of the University of Alcalá has developed the application DriveSafe that monitors and evaluates the driving profiles of the drivers generating alerts in real time when they are considered to be unsafe. Placing the mobile device on the vehicle's windshield, the application uses the smartphone's sensors (accelerometers, GPS, rear camera) to get a complete assessment of the driving and create a driver profile that can be checked either on real time during the trip, or reviewed in detail once the route is over. The system requires only a slight calibration. The application has a dual functionality. On the one hand, it provides real-time Advanced Driver Assistance Systems (ADAS) services, improving the safety of drivers in all types of vehicles (mainly low-end), which otherwise would only be available in premium vehicles high-end. On the other hand, it generates a history of the driver behavior that may be useful to the driver himself or to insurance, logistics or other companies in order to mitigate potential risks and reduce operational costs. The group is looking for companies from the Transport, Insurance or Apps sector to sign technical collaboration agreements, commercial agreements with technical assistance and license agreements.
Itzel Saldivar posted this:
DRONA: Software requirements management tool for Enterprise ArchitectThe tool is built as an add-in for Enterprise Architect - designed and tested for (1) defining, modelling, and optimizing technical requirements, (2) requirements authoring support, (3) reconciliation between requirements models, and (4) automated generation of full deliverables, as well as (5) acceptance criteria written as Gherkin test scenarios.
Tech Transfer Officer at SnT- Brunel University LondonBrunel University London
Brunel University London posted this:
DRooTES: Double Rooted Trailing Edge Serrations for quiet bladesAerofoil blade designs with double rooted serrations that reduce trailing edge noise to the maximum through destructive interference. They can be attached to existing blades so are particularly suitable for retrofitting to larger blades, such as wind turbines. They are however applicable to a wide range of blades moving in air and water, for example turbines, fans, rotary wings and fixed wings. The scale of application ranges from small drones (small blades operating at high speeds) to large wind turbines (large blades operating at slower speeds).
Germans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research Institute posted this:
Drug Delivery PlatformColonoscopic procedures have become widespread in recent years since colorectal cancer (CRC) and inflammatory bowel disease (IBD) have become prevalent disorders. Their use has expanded as diagnostic and therapeutic tools in both elective and emergency situations. Colorectal cancer (CRC) is the most common cancer in both men and women. In the case of polypectomy, as in the case of surgery, the stabilization of the primary tumors could allow the use of optimizing chemotherapy and therefore an overall improvement in the treatment of the disease.
Larisa SheloukhovaKyoto UniversityLarisa Sheloukhova posted this:
Drug discovery for Charcot-Marie-Tooth Disease Using Patient-Derived iPS Cell LinesCharcot-Marie-Tooth disease (CMT) is one of the most common rare diseases affecting approximately 1 in 2,500 - 5,000 people, or 3 million people in total worldwide. It is characterized by progressive peripheral neuropathy. The disease appears in two main forms: demyelination of the myelin sheath, which is formed by Schwann cells wrapping around the axon, or degeneration of the axon itself. There are various types of CMT caused by mutations in different genes. CMT1A, caused by a duplication of the PMP22 gene, is the most common demyelinating type, affecting ~50% of individuals with CMT. CMT2A, caused by mutations in the mitofusin-2 (MFN2) gene, is the most common axonal defect type. Gene therapies and small molecules are under development for different CMT types, however, there are currently no available treatments or cures for CMT patients. SCAD is a spin-off from Kyoto University that specializes in the development of disease models using patient-derived iPS cell lines for CMT1A and 2A, conducting drug discovery research to clarify pathology and explore therapeutic drugs, as well as pursuing cell therapy for neuropathies using pluripotent stem cells.
Global Tech Commercialization at Kyoto University
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Drug repurposing against pneumococcus and other Streptococcus genus speciesCSIC has developed a patent for the use of 7 drugs as novel antimicrobials that display bactericidal activity against Streptococcus pneumoniae (pneumococcus), acting on therapeutic targets not considered in the usual treatments for this pathogen. Industrial partners are sought which are interested in patent licensing for the development of the mentioned drugs as antibacterials targeting the Streptococcus genus and that open up new ways for treatments against these pathogens and for combating current antibiotic resistance issues.
IDIBELL posted this:
Drug repurposing for lupus nephritis therapyDrug repurposing for lupus nephritis therapy. Compound X, already approved for human use in other medical indications, administered orally, can be repurposed for lupus nephritis treatment. The principal goal of compound X therapy in lupus nephritis is to normalize renal function or, at least, to prevent the progressive loss of renal function. ✓ Less side effects than the standard of care ✓ Already approved for human in other medical indications (Reprofiling) ✓ Market with 1 approval in last 50 years
NDI Foundation posted this:
DSP - digital signal processor of new generationThe project offers new assembler, that’s High level assembler and New core of processor’s architecture. The invention is new generation device for signals processing. The proposed assembly language is based on a formulaic recording of mathematical operations, which greatly improves the process of creating programs and their debugging. Program language maximally adapted to the processing of data arrays, tables, etc. Temporary programming costs are reduced repeatedly and commensurate with programming in C, and in some cases even less, and resulted with efficient assembly code. Developed prototype of core DSP implemented and successfully tested. Complete set for work with the processor and software: simulator, compiler, debugger system tests, library routines etc. Prepared patent applications, including patent applications for DSP core architecture and instruction set, as well as some of the functional blocks. The developed core can be a base for a number of circuits intended for different applications. The proposed architecture of the core is not the final possible product. Currently the architecture of the microcontroller and the next version of DSP core with a flexible architecture and programming language are under development.
University of Granada (OTRI)University of Granada (OTRI)University of Granada (OTRI) posted this:
Dual Probes for Flow Cytometry and Mass CytometryResearchers of the University of Granada have developed probes based on nanoparticles, both fluorescent and functionalized with metals, which act as dual probes, and can be used for both flow cytometry (FACS –Fluorescent-Activated Cell Sorting) and mass cytometry (CyTOF -Cytometry by Time-Of-Flight-). The probes can be used for bar coding of living cells or carrying out in vivo studies of different cell lineages through cell co-cultures as well as the activation of drug precursors through cytoplasmic catalysis of organometallic reactions inside living cells.
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Dual-Electrode in situ Infrared Spectroscopy for Fuel Cells and Batteries- Utilizes dual-electrode in situ/operando infrared spectroscopy enabling spectroscopic access to both the anodic and cathodic reactions of a fuel cell or a rechargeable battery during operation. - Allows for the measurements of chemical species in anodic reactions and chemical processes of forming and deteriorating solid-electrolyte interphase (SEI) through use of ATR-IRS measurements. - Enhances understanding of operational chemistry of fuel cells and rechargeable batteries, potentially improving their performance and efficiency.
Chicagoland Automation posted this:
Dual/Triple Sump pump controller with optional bluetooth or Wifi connectivityDual sumpump controller with redundant level sensing and % level showing. Optional Bluetooth/ Wifi connectivity for mobile app or IOT. One primary and one secondary back up pump, Automatic testing of back up pump when water level rise rate is slow. Pump start/stop will vary within programmed range and depending on water level rise to minimize start / stop cycles. Option for third pump.
University Hospital Hradec KrálovéUniversity Hospital Hradec KrálovéUniversity Hospital Hradec Králové posted this:
Dually Acting Tacrine Derivatives for Treatment of Neurodegenerative Disorders - A dually-acting compounds with neuropsychopharmacological and drug-like properties with potential therapeutic useNeurodegenerative disorders (ND) accounts the vast majority of age related dementias characterized by progressive cognitive decline of higher mental functions. The research devoted to this field uncovered a pathomechanism of complex multietiology which cannot be addressed by hitting one target. Motivated by currently available treatment against ND involving the inhibitors of acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDAR), administered also in combination, we developed dually-acting compounds based on 1,2,3,4-tetrahydro-9-aminoacridine (tacrine) structure and confirmed their neuropsychopharmacological and drug-like properties for potential therapeutic use. Only a few compounds have been established for the treatment of Alzheimer’s disease. For instance, FDA and EMEA have approved three cholinesterase inhibitors, one NMDA-receptor antagonist – memantine and one disease-modifying immunotherapy – aducanumab, for Alzheimer’s disease (AD). Here we offer a combination of both effect in a single molecule. To date there are many other drugs undergoing clinical trials in AD, having various mechanism of action (vaccines against amyloid beta, against Tau protein, antiinflammation drugs) but none of them seems to reach the registration in a short term. Novel molecules represent a new way how to cope with the multiple pathogenic factors of ND. Based on our observations, we suppose that these compounds are able to hit additional targets relevant to ND and thus succeed in overcoming the multifactorial pathogenesis. While tacrine (approved for AD treatment in 1993) was withdrawn from the market due to its hepatotoxicity and other side effects in 2013, our compounds were prepared to avoid this hepatotoxic effect as we demonstrated in in vitro studies. Since these compounds have also been found acting as GluN2B selective NMDAR antagonists, they are therefore believed to hold strong therapeutic potential in the treatment of other disorders – e.g. ischemic damage, chronic pain and depression. Authors would like to thank the grant of Ministry of Education, Youth and Sports of the Czech Republic (project ERDF no. CZ.02.1.01/0.0/0.0/18_069/0010054). 1. https://pubmed.ncbi.nlm.nih.gov/33892271/ 2. https://www.sciencedirect.com/science/article/abs/pii/S0006295221000563?dgcid=rss_sd_all 3. https://www.tandfonline.com/doi/abs/10.1080/01480545.2019.1566350?journalCode=idct20&
Helen Xu posted this:
Durable QR barcode tag for LPG cylinder trackingWe successfully developed permanent barcode tags for LPG gas cylinders,it will work together with gas cylinder tracking software system. Which use corrosion resistant metal as matrix and integrate barcode information with ceramic glaze. The barcodes are corrosion-resistant and aging-resistant,which corresponds to the long life time and hostile working environment of gas cylinders.The chemical stability,corrosion-resistance,abrasion-resistance and temperature-resistance of glaze are very reliable.So when we integrate barcode information with glaze,we can protect barcode information from aging,corrosion,abrasion and high temperature while using barcodes in hostile working environment. The special barcode labels produced by Xiangkang have competitive prices and are being used by more than 3000 gas filling stations around the country.In the recent ten years,we have sold 70 millions.There is no doubt that the quality and life time of our barcode tags can satisfy the real usage of gas cylinders.
R&D Manager at LPG cylinder tracking
Universitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPC posted this:
Dynamic control device for optimization and reduction of energy consumption in lighting of closed spacesA new methodology for the dynamic control of lighting in closed spaces has been patented and developed. The new device can be easily implemented in buildings and allows energy savings up to 85%. Partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.
PhD Isabel Gavilanes-PerezSpanish National Research CouncilPhD Isabel Gavilanes-Perez posted this:
Dynamic Pupil for ophthalmological applicationsResearchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a self‐regulating iris based on light‐actuated broadband absorber metamaterial. Manufacturing companies of contact lenses and/or ocular prosthesis are being sought to collaborate and/or exploit the existing know how through a patent license agreement.
Open Innovation Manager at Spanish National Research Council
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Dynamic Pupil for ophthalmological applicationsResearchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2) have recently developed a self‐‐regulating iris based on light‐‐actuated broadband absorber metamaterial. Manufacturing companies of contact lenses and/or ocular prosthesis are being sought to collaborate and/or exploit the existing know how through a patent license agreement.
Mitsu YamamotoJapan Technology Group, Inc.Mitsu Yamamoto posted this:
Dynamically-stable omnidirectional electric vehicleWe would like to propose a technology for dynamically-stable omnidirectional electric vehicle that vehicle body is always kept in upright position and consequently provides larger stability margin while driving. This technology from the research team at the Tokyo University of Science offers a technology of mechanism which is potential applicable for an innovative electric wheel chair or personal vehicle as well as a next-generation autonomous mobile robot or an automatic guided vehicle. The research team are currently willing to seek collaboration opportunity for further development.
Business Development Manager at Japan Technology Group, Inc.
E
Yeda posted this:
Early Detection and Treatment of Myeloid Leukemiamalignancies such as AML and MDS are usually aggressive and have a low overall survival rate. Recent studies demonstrated that specific mutations in hematopoietic stem cells occur years before the disease is diagnosed in individuals at high risk of developing myeloid malignancies. Therefore, there is a need to prevent disease development in those individuals. The group of Prof. Liran Shlush found that inhibition of a specific error-prone DNA repair mechanism (MMEJ) could reduce the likelihood to develop future myeloid malignancies in high-risk individuals.
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Early Warning System for Anaerobic Digesters The CSIC and University Pablo de Olavide have developed a system for warning possible failure of the anaerobic digestion process carried out in a digester, using a microbial fuel cell connected to the digester by recirculation. This system is called Previous Destabilization Alarm for Anaerobic Digesters (PDAL). Companies interested in the license of the patent are searched for commercial exploitation.
Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget posted this:
Early warning system for detecting deterioration in post intensive care patientsIn the UK 28% of deaths in patients treated on an Intensive Care Unit (ICU) occur after the patients return to the general ward. These patients often suffer late developing complications after initial successful treatment in the ICU. There is usually a period of deterioration when a patient shows some signs of developing a complication. PICRAM (Post Intensive Care Risk Adjusted Monitoring) is a system that watches over the electronic records of the vital signs of patients after discharge from an ICU. It analyses the information to estimate the likelihood that a patient will suffer a complication in the next 24-48 hours. Patients most at risk of complications can then be identified and specialist nurses sent to start treatment early to the patients who need them most. The early detection of deterioration provided by PICRAM can save lives and reduce treatment costs.
IMDEA Water Institute posted this:
Ecological assessment of groundwater and groundwater dependent ecosystemsAn integrated management of groundwater resources requires a complete monitoring of biological, ecological and physical-chemical water properties in order to enhance our understanding on the ecosystem services they provide. IMDEA Water offers environmental services and fauna survey in groundwater (GW) and groundwater dependent ecosystems (GDEs) (i.e. the hyporheic zone of rivers, wetlands) for the groundwater resource sector. In order to ensure an adequate quality of groundwater for urban and rural consumption and considering the protection of aquatic resources to accomplish the directives regulations concerning water resources (Water Framework Directive, WFD 2000/60/EC, Directive on Environmental Quality, DEC 2008/105/EC and Groundwater Directive, GWD 2006/118/EC), we offer our integrated environmental consulting service on ecological assessment of GW and GDEs using a combination of traditional and innovative techniques for monitoring, evaluation and ecological analysis of GW biotic communities. We provide cost effective project solutions and outstanding client relations by delivering scientifically rigorous surveys on groundwater ecosystems.
Universidad de AlicanteUniversidad de AlicanteUniversidad de Alicante posted this:
Ecological concretes and mortarsA multidisciplinary public-private research consortium has developed a simple and innovative process to transform submerged arc welding slag waste into activated materials (geopolymers) that can be used as environmentally friendly substitutes for Portland cement to manufacture concrete or mortar-based construction materials. These new materials are characterised by low production costs, are environmentally friendly, sustainable, do not generate waste in their production process, and have excellent physico-chemical properties. Companies interested in acquiring this technology for its commercial exploitation are sought.
IMDEA Water Institute posted this:
Economic analysis of water resources managementThe main lines of research of the group are: •Water management in areas vulnerable to extreme weather events: drought risk and water scarcity. •Tools and methods for assessing potential climate change impacts, costs & benefits, and risks & opportunities. •Link between science (i.e. water economics) and policymaking (i.e. EU Freshwater Policy). •Hydroeconomic analysis of water investments. •Economic analysis of biophysical flows of ecosystem services. •Groundwater management.
