Patrick Claude, PhD.

TECHNICAL AND SCIENTIFIC PROFILE

Research Experiences

Several years of experience in synthetic methodology, small molecules, multi-step synthesis, optimization of reaction conditions of small to large scale synthesis of natural compounds that have application to SAR, Bio- Conjugation, Biopharmaceutical, as well as agricultural chemistry applications.

Four years’ experience Consulting in Heterocyclic Chemistry and Natural Products for devising and advising efficient synthesis of Beta-Lactams, (Applicable to Carbapenems), Benzodiazepines, various classes of Heterocyclic Alkaloids, Terpenes, Sesquiterpenes, Asymmetric Synthesis, Synthesis of small molecules and medium complex intermediates, amino acid derivatives, short peptides, Peptidomimetics, Carbohydrates, and compounds as Active Pharmaceutical Ingredients, (API).

Several years’ of experience in manipulating air sensitive compounds, and the use of organo-metallics such as Rhodium, Cobalt, and Palladium, Organisilicon for synthesis of various compounds. Use of palladium complex reagents to carry Heck, Susuki, Stille, Sonogashira coupling and intramolecular reactions for Carbon-Carbon bond formation in synthesis of Cyclic Acetogenins

Achieved, and conceived multi-step synthesis of natural product synthesis of cyclic compounds such as terpene, sesquiterpene, C-C bond formation, asymmetric synthesis of small molecules, natural products, synthesis of heterocyclic compounds, lipids, glycolipids, and glyco- amino lipids compounds. Achieved synthesis of complex cyclic acetogenins as pesticides and fungicides for crop protection, cross metathesis reactions, coupling and cyclization reactions with palladium complexes.

Several years of experience in Carbohydrate Chemistry, modification of Carbohydrate, Functional Groups Modification. Elaborated, conceived and achieved synthetic methodology for construction of difficult glycosidic bonds by a synthetic methodology called Intramolecular Glycosylation unrealizable by conventional glycosylation. These glycosidic bonds are present in many natural compounds that display interesting biological activities as anti-cancer, anti-cardiac agents and anti- viral agents, such as Saponins, Glyco-Anthracyclines and various other glycoconjugates, application to Carbohydrate Polymers, Carbohydrate Dendrimers, Oligosaccharide Synthesis, Protein Binding, Biocatalysis,

Two years’ experience in Process Chemistry, worked in clean GMP laboratories in medium to large scale of monosaccharides, disaccharides, trisaccharides, to be used for preparation of polysaccharides vaccines.
Applicable to Synthesis of Carbohydrate Polymers, Carbohydrate Dendrimers, SAR Analysis, Bioconjugation, and Guar Gum Synthesis and Click Chemistry.

Experience in Process Chemistry, Process Optimization, and Generation Process Data, worked in clean GMP Laboratory Clean Room. In medium large and large scale of diverse monosaccharides, small molecules for preparation of large glycoconjugates vaccines. Writing reports in Laboratory notebooks in SOP model strictly conform to GMP Regulations. Achieved parallel synthesis of various natural products, heterocycles, carbohydrates, and glycoconjugates.

Experienced in synthesis of amino acids derivatives, solution and solid phase synthesis of peptidomimetics.
Applicable to Peptide Nucleic Acids, (PNA), and Protein Chemistry.

ANALYTICAL AND COMPUTER SKILLS

More than ten years’ experience in characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), Mass, IR-UV spectroscopy.
Many years’ experience in techniques of purification and separation of many classes of compounds by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography, GC-MS, LC-MS. Several year of experience and knowledge in the utilization of chemistry search program soft wares such as Sci-Finder, Reaxys, File Registry Chemical drawings (STN) and CAPLUS File Registry, Chemsketch, Chemwindows, Chemdraw, NMR-programs to retrieve and process 1 -and 2 –dimensional NMR spectrums. Others: PowerPoint, MS-Word, Word Perfect, Excel, Windows 1998, 2000, 2003-2013.

TEACHING EXPERIENCE:
Successful years of experience working as a chemistry lecturer and tutor
Sound knowledge and understanding of instruction theory and practice.
Ability to work collaboratively with administration and colleagues.
Excellent oral and written communication with leadership qualities.
Strong interpersonal and organizational skills.
Excellent motivation and instructional skills.
Many years’ experience in developing questions for Examinations with comprehensive rationale,
as well as correction of examinations.
Many years’ experience in tutoring Sciences General Chemistry, Organic Chemistry, Advanced Organic Chemistry, Physical Chemistry I, (Thermodynamics), Analytic Chemistry, (Quantitative Analysis), High School Chemistry, AP and Normal Level, Mathematics, (Algebra I , II, Trigonometry, Pre-Calculus) , French Tutoring to College, High School , Junior High School and School Level Students.
Fluent in English, French, German, (speaking and writing), have taught, tutored in all three languages.

Junior Patent Examiner Experience

Junior patent examiner in Organic Chemistry, Biotech, Pharmaceutical.
Skills of patent examining applications for scientific inventions, search of prior art by using multiple scientific and patent search software toward finding prior art. Use of scientific specialty to determine prior art, patentability or non-patentability of organic chemistry inventions pertaining to Biotech-Pharma.