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Elaboration of platform technologies for sustainable production of active pharmaceutical ingredients (API) from biomass and using sustainable ressources, respectful to the environment and clima change.
Development of natural products as drugs against addiction and pain management.
Givaudan SA
January 1991 - December 1996
Geneva
GK Amenities
December 1996 - January 2001
Geneva
BASF
June 2001 - February 2009
Extranthis UG (DE) & CORYN Pharmaceuticals LLC (USA)
February 2009 - Present
Ludwigshafen
University of Neuchâtel - Switzerland
January 1980 - January 1983
Chemistry
University of Neuchâtel - Switzerland
January 1983 - January 1987
Organic Chemistry
University of Neuchâtel - Switzerland
January 1987 - January 1988
Organic Synthesis
Columbia University NY - USA
January 1988 - January 1989
Neurochemistry
University of Neuchâtel - Switzerland
January 1989 - January 1991
Organic Synthesis
Our developed technology relates to the use of vegetable oil, a sustainable and green material, for the extraction and production in large scale of specific and highly useful alkaloid drugs as Active Pharmaceutical Ingredients (API), from biomass.[…]
Drug development of a natural product which presents a strong potential to treat addiction to opioids without developing addictive side effects to patients.[…]
- We provide supply of cGMP cytisine API in bulk, produced in FDA inspected installations in the USA, for use as smoking cessation agent. - We develop a small molecule (natural product) for treatment of opioids use disorder and for pain management.[…]
1. Synthèse des (1)-(6R)- et (+)-(6S)-tétrahydro-6-[(Z)-pent-2-ényl]-2H-pyran-2-one, lactones de Jasminum grandiflorum L.- et de Polianthes tuberosa L.. Helv. Chim. Acta. 74, 787¬790, (1991).
see publication
2. Synthèse énantiospécifique du (1)-(1S,3R,5R)-1,8-diméthyl-3-éthyl-2,9-dioxabicyclo [3.3.1]non-7-ène. Helv. Chim. Acta, 74, 1233-1235, (1991).
see publication
3. Structure-activity relationships of Philanthotoxin analogs and polyamines on N-Méthyl-D-Aspartate and Nicotinic Acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics, 254, 764-773, (1990).
see publication
4. Structure - activity relationships of analogues of the wasp toxin Philanthotoxin : Non-competitive antagonists of quisqualate receptors. Toxicon, 28, 1333-1346, (1990).
see publication
5. Philanthotoxine-433, (PhTx-433), a non-competitive glutamate receptor inhibitor. Pure Appl. Chem., 62, 1223- 1230, (1990).
see publication
6. Synthesis of glutamate receptor antagonist Philanthotoxine-433 (PhTx-433) and its analogs. Tetrahedron 46, 3267-3286, (1990).
see publication
7. Synthèse énantiospécifique du (1)-(1R,3R,5S)-diméthyl-1,3-dioxa-2,9-bicyclo-[3.3.1] nonane. Helv. Chim. Acta, 72, 1284-1287, (1989).
see publication
8. Synthèse énantiospécifique de la (+)-(R)-éthyl-6-dihydro-2,3-méthyl-2-4H-pyranone-4, phéromone de la mite Hepialus Hecta L.. Helv. Chim. Acta, 72, 1259-1261, (1989).
see publication
9. Synthèse énantiospécifique des acides (+)-(2R) et (-)-(2S)-éthyl-6-dihydro-3,4-méthyl-2-oxo-4-2H- pyranecarboxylique-5. Helv. Chim. Acta, 72, 731-737, (1989).
see publication
10. Structure of 1,5-Di(1-pyrrodinyl)-4-hexene-1,3-dione. Acta Cryst., C43, 2155-2157, (1987).
see publication
11. EP2292629 Method of isolating cytisine from biomaterial.
see patent at European Patent Office database
12. WO2011026637 Methods for isolating alkaloids from plants.
see patent at the European Patent Office database