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Sergey Klykov
Innovation Consultant at Alpha-Integrum, Ltd.
Russian Federation · Moscow regionJoined April 2012
Describe it (summary)
https://fermentertool.com/en/
Academic Studies (2)
Master's degree
Dmitry Mendeleev University of Chemical Technology of Russia
January 1980 - January 1986
Chemistry, Biotechnology and other
http://www.muctr.ru/en/
PhD
Federal Budget Institution of Science STATE RESEARCH CENTER FOR APPLIED BIOTECHNOLOGY & MICROBIOLOGY
January 1986 - January 1996
Biotechnology
http://www.obolensk.org/eng/index.htm
RESEARCH
SRCAMB conducts research in the field of epidemiology, bacteriology and biotechnology to assure an appropriate level of sanitary and epidemiology welfare for the population of the Russian Federation.
Center has a required infrastructure and qualified staff to carry out research involving various pathogenic microorganisms, including those of especially dangerous infections of the bacterial origin in humans and animals.
In the Center there is an animal facility equipped in compliance with modern requirements for handling small laboratory animals, including SPF animals (rabbits, hamsters, mice and rats). There is an installation for aerogenic challenge of animals.
Research areas of interest (13)
- Cellular and Molecular Biology Technology
- Microbiology Technology
- Bioinformatics Technology
- Software services
- Microbiology Market and 8 more
A cell population structuring model to estimate recombinant strain growth in a closed system for subsequent search of the mode to increase protein accumulation during protealysin producer cultivation
S P Klykov, V V Kurakov, V B Vilkov, I V Demidyuk, T Yu Gromova and D A Skladnev.
http://iopscience.iop.org/article/10.1088/1758-5082/3/4/045006/meta
Abstract
In this paper we have proposed a new structured population growth model, further developing a model previously proposed by the authors. Based on this model, optimal growth characteristics of the recombinant strain Escherichia coli BL-21 (DE3) [pProPlnHis6] were determined, which allowed us to increase the output of metalloproteinase by 300%. We have experimentally demonstrated the applicability of the new model to cell cultures with implanted plasmids and the potential practical use for an output increase of a wide variety of biosynthesis processes.
Sergey Klykov didn't publish any Technology Call yet
A cell population structuring model to estimate recombinant strain growth in a closed system for subsequent search of the mode to increase protein accumulation during protealysin producer cultivation
S P Klykov, V V Kurakov, V B Vilkov, I V Demidyuk, T Yu Gromova and D A Skladnev.
http://iopscience.iop.org/article/10.1088/1758-5082/3/4/045006/meta
Abstract
In this paper we have proposed a new structured population growth model, further developing a model previously proposed by the authors. Based on this model, optimal growth characteristics of the recombinant strain Escherichia coli BL-21 (DE3) [pProPlnHis6] were determined, which allowed us to increase the output of metalloproteinase by 300%. We have experimentally demonstrated the applicability of the new model to cell cultures with implanted plasmids and the potential practical use for an output increase of a wide variety of biosynthesis processes.
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