Rohan Joy Mathew

- A novel method of obtaining patient telomere length data through the collection, processing, and analysis of genomic DNA derived from a biological sample - Method for the diagnosis of telomere-related conditions and diseases in patients, with the ability to monitor various aspects of patient healt[…]

- Identify likely infected individuals, including those exhibiting minimal symptoms. - Support automated, efficient contact tracing - Require minimal user cognizance of testing procedures[…]

- Innovative fluorescent sensors that rapidly assess the enantiopurity of diverse chiral compounds, aiding pharmaceuticals, agrochemicals, flavors, and more. - Replace slow chromatography, enable fast HTS enantioselectivity screening, and assess compound stability with in situ detection. - Revolutio[…]

- High-quality speech synthesis across multiple languages and accents with a single voice model - Personalized speech synthesis capabilities, which enable users to utilize their own voices - Requires less training data and allows for voice transformation[…]

- Development of an Eastern woodchuck animal model that produces a human HBV infection in the woodchuck animal through the administration of a new HBV-WHV chimeric virus - This new animal model may be used to study acute and chronic WHV and HBV infections in the same host for comparison of immunopat[…]

- Non-invasive methods for diagnosing and monitoring liver disease - Availability of a biomarker assay for the antifibrotic and anticancer effect of proglumide - Proglumide, with proven safety in human peptic ulcer trials, is orally bioavailable[…]

- Targets cancer cells with CCK-B receptors, significantly impacting pancreatic cancer treatment - Utilizes biodegradable, non-toxic nanoparticles for efficient siRNA delivery - Offers potential for broader application across various cancers expressing similar receptors[…]

- Gait analysis can be used to diagnose injury and disease - Take-home solution using inexpensive, lightweight sensors and artificial intelligence - Can potentially reduce falls and healthcare costs in vulnerable populations, a major source of medical expense nationwide in the United States[…]

- Histone deacetylase (HDAC) inhibitors, with applications for treating cancer, neurodegenerative disorders, neurological diseases, stroke, malaria, autoimmune diseases, autism, and other conditions - Compounds are highly selective inhibitors of the HDAC6 subtype - Method does not cause potential ge[…]

- A practical approach to determine the absolute configuration, concentration, and enantiomeric excess of chiral compounds. - The method employs simple, inexpensive materials and produces minimal wastage. - An inexpensive sensing method for High throughput application, more specifically employed in […]

- Potential to suppress tumor growth and cancer cell proliferation. - Treatment with a synergistic combination of YAP/SOX2 inhibitor(s) that effectively induce cancer cell death and tumor growth arrest in YAP-dependent cancer cells - Overcome SOX2-mediated resistance to YAP inhibitors in cancer cell[…]

- Allows indefinite expansion of human germline pluripotent stem cells (gPSCs) from biopsy in a specialized cell culture medium, enabling their use in regenerative medicine. - Overcomes slow growth, differentiation, graft rejection, and tissue availability issues, facilitating hgPSC transplantation […]

- Innovative fluorescent sensors that rapidly assess the enantiopurity of diverse chiral compounds, aiding pharmaceuticals, agrochemicals, flavors, and more. - Replace slow chromatography, enable fast HTS enantioselectivity screening, and assess compound stability with in situ detection. - Revolutio[…]

- A practical approach to determine the absolute configuration, concentration, and enantiomeric excess of chiral compounds. - The method employs simple, inexpensive materials and produces minimal wastage. - An inexpensive sensing method for High throughput application, more specifically employed in […]

- Topical mTOR-I may be effective in treating numerous cutaneous vascular and proliferative conditions - Potential to improve many rare and unmet dermatologic conditions for patients - Addresses unmet needs in dermatology, providing a novel approach to treating challenging skin conditions[…]

- A foldable, manually transportable solution with low power requirements, ideal for under-resourced settings and emergency situations. - Combining body temperature regulation and full resuscitation capabilities, the device significantly increases newborn survivability in resource-constrained enviro[…]

' Provides early detection of pancreatic cancer, significantly increasing the potential for successful treatment outcomes ' Utilizes targeted nanoparticles, enhancing specificity and reducing false positives in diagnostic imaging ' Supports the development of personalized medicine approaches by enab[…]

- Demonstrates over 96% efficiency in filtering submicron particles, including PM0.3, crucial for public health and environmental protection - Offers a robust and reusable solution, significantly reducing environmental waste compared to traditional filters - Possesses strong mechanical properties an[…]

- Innovative chiral bisoxazolidine ligand enables economical synthesis of chiral alcohols from aldehydes. - Ideal for pharmaceuticals and intermediates, with high yields and enantioselectivities in various reactions. - Utilizes low-cost alkyl-zinc reagents and offers ligand recycling, ensuring cost […]

- A group of novel small molecules that are phenyl-substituted nicotinic desensitizer ligands with a high affinity and selectivity for α4β2 nAChR subtypes. - The potential characterization of the compound VMY-2-95 and its analogs as a nicotinic acetylcholine receptor (nAChR) antagonist in animal mod[…]

- Accurately prediction of the risk of colorectal cancer recurrence by analyzing six microRNAs (miRNAs) in patient samples. - The miRNA panel provides distinctive signatures for identifying the source of metastases and correlates with recurrence-free survival. - The method enables personalized treat[…]

- A group of novel small molecules that are 2,5-disubstituted-pyridyl nicotinic ligands with a high affinity and selectivity for α4β2 nAChR subtypes. - Potential characterization of nicotinic acetylcholine receptor (nAChR) antagonist in animal models for developing new therapeutics to treat addictio[…]

- Potential treatment for diabetes, obesity, and related metabolic diseases. - The protein FGFBP3 enhances FGF binding affinity, causing long-term reduction in hyperglycemia and gluconeogenesis in affected patients. - Safer alternative to current diabetes treatments, as it does not cause life-threat[…]

- A device to determine miRNAs' presence in interstitial fluid (ISF) through transdermal microfluidic technology. - Addresses the requirement for minimally invasive or noninvasive methods to detect circulating miRNA biomarkers. - By utilizing interstitial fluid (ISF) instead of blood, plasma, or ser[…]

- NMC cell lines from the pleural fluid and bone marrow aspirate of a pediatric patient diagnosed with thymic carcinoma. - Unique karyotypic abnormality, an original viable cell line from a pediatric patient (1997). - Potential use for drug screening and therapeutic research; allows exploration of i[…]

- Novel method to identify tumor-specific antigens for cancer immunotherapy. - Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing to identify neoantigens or potential neoantigens as predictive biomarkers and synergistic treatment targets for cancer immunotherapy. - Method uncovers antigens […]

- Potential use in the treatment of respiratory distress syndrome (RDS), asthma, chronic obstructive pulmonary disease (COPD), HIV/AIDS-related lung diseases (PJP infection), tuberculosis, and severe acute respiratory distress syndrome. - Synthetic lung surfactant composed of Silk fibroin, easy to m[…]

- Potential minimally invasive method for monitoring the presence and progression of liver diseases and cancer. - Quantification of glycoprotein biomarkers using LC-MS-based glycoproteomic profiling of patient sera and informatics approaches.[…]

- Promising therapeutic agent for metastatic osteosarcoma. - The benefit of reduced toxicity compared to traditional chemotherapeutic methods. - Potential to advance the development of novel therapies for cancer.[…]

- Potential to suppress tumor growth and cancer cell proliferation in patients with neurofibromatosis 2 (NF2) mutations. - A treatment with YAP/TAZ inhibitor(s) that effectively hinders glycolysis in NF2-mutant cancer cells, halts tumor growth, and overcomes resistance to YAP/TAZ inhibitors. - Use o[…]

- A novel approach to pharmacologically upregulate PGC-1α, providing protection against neurodegeneration. - Proven efficacy in the prevention and treatment of various neurodegenerative conditions, such as Parkinson's Disease, Parkinson-plus syndrome, familial dementia, Alzheimer's Disease, Hunti[…]

- Non-invasive, affordable biomarkers can predict Alzheimer's disease (AD) progression, defining the asymptomatic period and enabling timely intervention. - Clinical indicators capable of differentiating Alzheimer's from Frontotemporal Dementia and aiding in identifying at-risk individuals for treat[…]

- Targets lung cancer stem cells and restores sensitivity to cisplatin and EGFR inhibitors. - Overcomes limitations of existing SLC25A1 inhibitors in crossing cell membranes effectively. - Offers the potential as a therapeutic option for hard-to-treat tumors and mutational landscapes.[…]

- A novel J-tube novel that provides a solution for situations requiring the bypassing of the stomach, allowing direct feeding into the intestinal tract for patients in need. - Overcomes the issue of leakage commonly encountered by a significant number of patients who require the use of feeding tube[…]

- Innovative High-Frequency Nasal Cannula (HIFI-NC) used for spontaneously breathing infants to avoid intubation or - postextubation respiratory support. - Portable, lunch box-sized, battery-operated, positive end-expiratory pressure (PEEP), and adjustable device. - Generates adjustable frequency vi[…]

- A new method utilizing tumor biopsies and zebrafish xenografts to predict CAR-T therapy response before treatment. - Reliable prognostic model for human cancer treatments, ensuring high effectiveness of CAR-T cells in patients with limited treatment options. - Cost-efficient, fast, and high-throug[…]

- Minimally invasive transdermal device for delivering an antimicrobial to skin at access point of interstitial fluid sampling, medical monitoring, and/or transdermal drug delivery. - Mitigates risk of infection at surgical and other wound sites. - Can deliver multiple antimicrobials to the site at […]

- Rapid and simultaneous determination of the absolute configuration, enantiomeric composition, and overall concentration of free-form cysteine - Overcomes interference from biothiols and other amino acids - Compatible with aqueous solutions e.g., body fluids[…]

- Minimizes time and chemical waste - Facilitates asymmetric reaction screening - More economical than previous technologies -----------------------------------------------------------------------------------[…]

- Simplified sensing assay with reduced cost and waste - Achievable with ligand-free, earth-abundant cobalt salts - Determination of the absolute configuration and the enantiomeric composition of the chiral analyte[…]

- A practical method to synthesize Tetrataenite thin films, a material with high magnetic anisotropic - Use of rare-earth-free and precious-metal-free material, this synthesis method is more cost-efficient in device fabrication - Used in magnetic memory devices, e.g., ultrahigh-density heat-assisted[…]

- Chemisorption of earth-abundant material on ferromagnets induces large Dzyaloshinskii-Moriya Interaction and Perpendicular Magnetic Anisotropy - More cost-effective by replacing those rare noble metals in device applications - Open up new possibilities of using chemisorption to design and tailor s[…]

- Automated image enhancement system for restoring document legibility. - No requirement for training data, making it versatile and language-independent. - Addresses the challenge of preserving and recovering details from degraded documents effectively.[…]

- PEP7 peptide and analogs provide targeted modulation of Ang II receptor pathways, presenting a novel therapeutic approach for hypertension management. - Selective inhibition of the Ang II signaling pathway (Erk 1/2) offers effective hypertension control with potentially fewer side effects than cur[…]

- PEP7 peptide and analogs provide targeted modulation of Ang II receptor pathways, presenting a novel therapeutic approach for hypertension management. - Selective inhibition of the Ang II signaling pathway (Erk 1/2) offers effective hypertension control with potentially fewer side effects than cur[…]

- A flexible drug delivery patch with sealed reservoirs that can be used to deliver macromolecular drugs directly to the circulatory system, which is a well-tolerated, non-invasive, and patient-friendly mode of treatment - In contrast to pulsatile drug treatment, transdermal delivery has the ability[…]

- A pharmaceutical composition comprising a solubilized SLC25A1 inhibitor for treating non-alcoholic fatty liver disease (NAFLD) has been shown to halt the evolution of non-alcoholic steatohepatitis (NASH) reverting steatosis, decrease inflammation, decreas - The SLC25A1 inhibitor may be administere[…]

- Potential to prevent or reduce weight gain, obesity, as well as the onset of metabolic syndrome and related diseases associated with dietary factors. - Promising drug treatment that targets a neutral amino acid transporter in fat cells. - A pharmaceutical composition that can be administered syste[…]

- Novel crystalline cavitand compositions with unique void spaces for efficient gas separation and storage. - Utilizes molecular/organic synthetic chemistry to enhance synthetic variability and efficacy in industrial applications - Versatile applications extend beyond gas separation, offering potent[…]

- The technology allows for the simultaneous determination of absolute configuration, enantiomeric composition, and concentration, surpassing conventional methods - With capabilities for multiwell plate technology, the assay streamlines processes, enabling rapid screening of numerous samples - From […]

- Metabolic biomarkers for cognitive ability enables accurate identification of individuals at risk of memory impairment by analyzing metabolite levels in blood samples - By detecting subtle changes in metabolite profiles, this technology provides opportunities for early intervention and personalize[…]

- Provides a diagnostic technique to determine if a subject is at risk for developing as well as monitoring the progression of dry type AMD in a subject - Potential use in screening various compounds for their effectiveness in treating dry-type AMD - Prospective application for diagnostic and treatm[…]

- The method combines determining a chiral compound's concentration with assessing its absolute configuration or enantiomeric/and or diastereomeric composition using a single chiroptical assay format. This integration streamlines the analytical process and - The method successfully analyzes a wide r[…]

- Development of a novel ionically driven synthesis method to grow high-quality ordered manganese- nitride based magnetic materials - This manganese-nitride based films can be potentially integrated into existing spintronic devices such as MRAM, magnetic storage, and magnetic sensors - Exhibits perp[…]

- Innovative dansyl-carbazole compound effectively restores RASSF1A expression, potentially inhibiting cancer cell proliferation in androgen-independent prostate cancer - Fluorescent compounds enable intracellular visibility, facilitating targeted therapy and monitoring of treatment efficacy, offeri[…]

- Utilizes dual-electrode in situ/operando infrared spectroscopy enabling spectroscopic access to both the anodic and cathodic reactions of a fuel cell or a rechargeable battery during operation. - Allows for the measurements of chemical species in anodic reactions and chemical processes of forming […]

- Secure Inter-device Communication. Each jurisdiction (data owner) uploads sensitive data into a dedicated "black box". - Devices collectively establish case matches to determine which jurisdictions have a legitimate "need to know" specific pieces of information and only share the necessary informa[…]

- Provides improved signal detection for comprehensive analysis of electrochemical dynamics - Allows immediate feedback on reaction mechanisms, essential for refining experimental parameters - Requires minimal setup adjustments to seamlessly interface with standard NMR instruments[…]

- Enables sensing of very challenging chiral targets - Unmatched sensing scope and utility are demonstrated with alcohols having alpha, beta, theta or even gamma stereocenters and with an alcohol chiral by virtue of isotopic substitution - The reaction sequence enables in-tandem determination of the[…]

- Real-time, in vivo monitoring of genotoxic response as a result of exposure to environmental genotoxic agents in zebrafish model system - Use of a stable, transgene expressing vertebrate organism for reproducible results - Conditional expression of fluorescent proteins in the case of purposefully […]

- Detects and responds to threats in real-time, reducing data breach risks. - Enhances detection accuracy with adaptive learning, countering evolving cyber risks. - Integrates seamlessly with existing networks, ensuring cost-effective security improvements[…]

- An innovative electrocatalyst enhancement combining platinum (Pt) and lead ions (Pb2+) in electrocatalysts boosts performance and longevity, reduces costs, and enhances the efficiency of fuel cells. - Organic fuel cells, which utilize methanol or formic acid, address hydrogen storage and handling […]

- Real-time monitoring of vast data sources for early detection of food threats. - Ontology-based approach enables identification of unknown and surprising threats. - Automated system reduces reliance on human-based surveillance methods.[…]

- Proactively generates unique signatures for all document operations, enhancing internal security measures. - Enables real-time alerts for unauthorized access or modifications, ensuring immediate response capabilities. - Facilitates forensic analysis by preserving comprehensive digital fingerprints[…]

- Novel anti-fungal agents effective against drug-resistant Candida strains. - Reduced toxicity compared to traditional treatments like amphotericin B. - Suitable for high-risk groups, including HIV and cancer patients.[…]

- Breath-activated mask delivering peppermint compounds for bronchodilation. - Reduces symptoms of respiratory distress by simulating controlled breathing. - Portable, disposable, and over-the-counter accessible solution.[…]

- TRPV1 agonists safely increase blood pressure without impairing blood flow to vital organs. - Offers an effective alternative to adrenergic and angiotensin II treatments. - Formulated for rapid, parenteral administration in critical care settings.[…]

- Combines thymosin beta 4 with chemotherapy/radiation to target medulloblastoma and glioblastoma with high p53 levels. - Enhances cancer cell targeting while minimizing damage to normal cells, improving treatment outcomes and patient safety. - Applicable for both pediatric and adult brain cancers, […]

- Transforms auditory speech into vibrotactile feedback for improved speech perception. - Enhances speech recognition in noisy environments or for hearing-impaired individuals. - Utilizes an array of vibrotactile transducers to generate distinct vibration patterns.[…]

- Targets CD99+ cancers with specific small molecule inhibitors for improved treatment efficacy. - Utilizes membrane impermeable CD99 inhibitors to enhance therapeutic specificity. - Provides a dual application in treating both cancer and autoimmune disorders.[…]

- Dual-material 3D printing with a pectin-based sacrificial layer allows for precise control over scaffold porosity and channel formation. - The hydroxyapatite scaffold provides strong mechanical support while promoting biological integration with host tissue Enables the creation of customized bone[…]

- Utilizes high entropy alloys as a new platform to stabilize high magnetic anisotropy materials with optimized physical properties. - Eliminates the need for rare-earth elements, reducing costs and supply chain risks. - Utilizes boron to stabilize complex crystalline phases in high entropy alloys[…]

- Enables real-time analysis of chemical status, enhancing precision and efficiency across automotive and batteries industries. - Improves fuel cell/rechargeable battery diagnostics by enhancing signal-to-noise ratio and reliability, overcoming magnetic susceptibility challenges effectively. - Imp[…]

- The LNA Gapmer specifically targets gastrin mRNA in CCK-BR positive cancer cells, reducing tumor growth。 - The use of LNA chemistry ensures the Gapmer's stability and longevity in vivo, leading to sustained therapeutic effects。 - Preclinical studies show significant reduction in tumor growth and[…]

- Enhances sensitivity of gastrointestinal tumor cells to oxaliplatin, improving treatment outcomes. - Targeted therapy for patients with HR-DDR mutations and/or a family history of breast or ovarian cancer syndrome. - Inhibits tumor growth, reduces size, and prevents metastasis of gastrointestina[…]

- Comprehensive, structured curriculum for training non-clinical ophthalmic assistants, ensuring foundational knowledge and preparation for certification - Adaptable for both in-person and online-distance learning, allowing broader access to quality ophthalmic education - Supports the rapid develo[…]

> Gait analysis can be used to diagnose injury and disease > Take-home solution using inexpensive, lightweight sensors and artificial intelligence > Can potentially reduce falls and healthcare costs in vulnerable populations, a major source of medical expense nationwide in the United States[…]