FoF1-ATP synthase localized in mitochondria presents energy production and membrane Permeability Transition Pore (mPTP) functionalities which, when dysfunctional, can cause mitochondrial or immunometabolic diseases. Purified F-ATP synthase in various oligomeric forms has also raised interest for conclusive in vitro testing because of its role in mPTP. To our knowledge, no protocol for F-ATP synthase oligomers separation has reached the desirable levels of quantity, stability or purity for high-resolution structural and functional analysis required for drug discovery.
Our purification method for FoF1-ATP synthase has shown excellent ability to produce the desired large amounts of human-derived FoF1-ATP synthase monomers, dimers, tetramers and oligomers, with high purity levels and while steadily retaining high levels of ATP synthase activity. We expect this method to be used for drug discovery purposes, research in drug targets for mitochondrial diseases and other applications.
We are looking for a partner who has the capability to develop a commercializable technology based on the applied patent and our researcher's knowhow. We are also open to suggestions for applications other than the ones mentioned below.
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Current development status
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Drug delivery target
Drug discovery
Mitochondrial diseases
Immunometabolic diseases
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Kyoto University was founded in 1897, the second university to be established in Japan. Kyoto University is among 10 National Designated Universities in Japan. It boasts 18 graduate schools, 10 faculties, 12 research institutes, and 26 centers and other establishments. Research conducted at Kyoto University spans the full spectrum of fields from social to natural science.
The outstanding research conducted at Kyoto University gives birth to useful technologies that could greatly benefit society. SACI (Society-Academia Collaboration for Innovation Office) was established at Kyoto University to bridge the gap between researchers and industry. We facilitate joint research, technology transfer, creation of university startups, and provide entrepreneurial education. We are building a strong network of global industry partners to make sure basic research reaches the market.
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